Recombinant人PON1 protein (ab53376)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human

相关产品

技术指标

Our Abpromise guarantee covers the use of ab53376 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    SDS-PAGE

  • 纯度> 95 % SDS-PAGE.

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 50% Glycerol, 20mM Tris, pH 8

常规信息

  • 别名
    • A esterase 1
    • A-esterase 1
    • Aromatic esterase 1
    • Arylesterase 1
    • Arylesterase B type
    • ESA
    • Esterase A
    • K 45
    • K-45
    • MVCD5
    • Paraoxonase
    • Paraoxonase 1
    • Paraoxonase B type
    • Paraoxonase, plasma
    • Paraoxonase1
    • PON
    • PON 1
    • PON1
    • PON1_HUMAN
    • Serum aryldiakylphosphatase
    • Serum aryldialkylphosphatase 1
    • Serum paraoxonase/arylesterase 1
    see all
  • 功能Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.
  • 组织特异性Plasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas.
  • 疾病相关Genetic variation in PON1 is associated with susceptibility to microvascular complications of diabetes type 5 (MVCD5) [MIM:612633]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Note=Homozygosity for the Leu-54 allele is strongly associated with the development of retinal disease in diabetic patients.
  • 序列相似性Belongs to the paraoxonase family.
  • 翻译后修饰Glycosylated.
    The signal sequence is not cleaved.
    Present in two forms, form B contains a disulfide bond, form A does not.
  • 细胞定位Secreted > extracellular space.
  • Information by UniProt

Recombinant Human PON1 protein 图像

  • SDS Page analysis of ab53376.
  • Anti-PON1 antibody [17A12] (ab24261) at 1/500 dilution + Recombinant Human PON1 protein (ab53376) at 0.01 µg

    Secondary
    Goat Anti-Mouse IgG H&L (HRP) preadsorbed (ab97040) at 1/500 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Exposure time : 1 minute

Recombinant Human PON1 protein (ab53376)参考文献

ab53376 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab53376.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"