Recombinant人PON1 protein (ab53376)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • 种属
      Human

技术指标

Our Abpromise guarantee covers the use of ab53376 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    SDS-PAGE

  • 纯度
    > 95 % SDS-PAGE.

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 50% Glycerol, 20mM Tris, pH 8

常规信息

  • 别名
    • A esterase 1
    • A-esterase 1
    • Aromatic esterase 1
    • Arylesterase 1
    • Arylesterase B type
    • ESA
    • Esterase A
    • K 45
    • K-45
    • MVCD5
    • Paraoxonase
    • Paraoxonase 1
    • Paraoxonase B type
    • Paraoxonase, plasma
    • Paraoxonase1
    • PON
    • PON 1
    • PON1
    • PON1_HUMAN
    • Serum aryldiakylphosphatase
    • Serum aryldialkylphosphatase 1
    • Serum paraoxonase/arylesterase 1
    see all
  • 功能
    Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.
  • 组织特异性
    Plasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas.
  • 疾病相关
    Genetic variation in PON1 is associated with susceptibility to microvascular complications of diabetes type 5 (MVCD5) [MIM:612633]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Note=Homozygosity for the Leu-54 allele is strongly associated with the development of retinal disease in diabetic patients.
  • 序列相似性
    Belongs to the paraoxonase family.
  • 翻译后修饰
    Glycosylated.
    The signal sequence is not cleaved.
    Present in two forms, form B contains a disulfide bond, form A does not.
  • 细胞定位
    Secreted > extracellular space.
  • Information by UniProt

Recombinant Human PON1 protein 图像

  • SDS Page analysis of ab53376.
  • Anti-PON1 antibody [17A12] (ab24261) at 1/500 dilution + Recombinant Human PON1 protein (ab53376) at 0.01 µg

    Secondary
    Goat Anti-Mouse IgG H&L (HRP) preadsorbed (ab97040) at 1/500 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Exposure time : 1 minute

Recombinant Human PON1 protein (ab53376)参考文献

ab53376 has not yet been referenced specifically in any publications.

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