Recombinant人Podoplanin / gp36 protein (ab87357)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • 种属
      Human
    • 序列
      MGSSHHHHHH SSGLVPRGSH MASTGQPEDD TETTGLEGGV AMPGAEDDVV TPGTSEDRYK SGLTTLVATS VNSVTGIRIE DLPTSESTVH AQEQSPSATA SNVATSHSTE KVDGDTQTTV EKDGLSTVTL
    • 氨基酸
      99 to 207

技术指标

Our Abpromise guarantee covers the use of ab87357 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度
    > 95 % SDS-PAGE.
    ab87357 is purified using conventional chromatography techniques.
  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 0.1M Sodium chloride, 20mM Tris, pH 7.5

常规信息

  • 别名
    • Aggrus
    • Glycoprotein 36 KD
    • Glycoprotein 36
    • gp 36
    • GP 38
    • GP 40
    • gp36
    • GP38
    • GP40
    • HT1A 1
    • HT1A1
    • hT1alpha 1
    • hT1alpha 2
    • hT1alpha1
    • hT1alpha2
    • Lung type I cell membrane associated glycoprotein
    • Lung type I cell membrane associated glycoprotein isoform a
    • Lung type I cell membrane associated glycoprotein T1A 2
    • OTS 8
    • OTS8
    • OTTHUMP00000009640
    • OTTHUMP00000044504
    • PA2.26
    • PA2.26 antigen
    • Pdpn
    • PDPN_HUMAN
    • Podoplanin
    • PSEC0003
    • PSEC0025
    • T1 alpha
    • T1 ALPHA GENE
    • T1-alpha
    • T1A
    • T1A 2
    • TI1A
    • TIA 2
    • TIA2
    see all
  • 功能
    May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels.
  • 组织特异性
    Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas.
  • 序列相似性
    Belongs to the podoplanin family.
  • 翻译后修饰
    Extensively O-glycosylated. Contains sialic acid residues. O-glycosylation is necessary for platelet aggregation activity.
    The N-terminus is blocked.
  • 细胞定位
    Membrane. Cell projection > filopodium membrane. Cell projection > lamellipodium membrane. Cell projection > microvillus membrane. Cell projection > ruffle membrane. Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles.
  • Information by UniProt

图片

  • 15% SDS-PAGE showing ab87357 (3µg).
    Note: Real molecular weight on SDS-PAGE is shifted up compared to predicted molecular weight.

文献

ab87357 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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