Recombinant人Podoplanin / gp36 protein (ab117687)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ86YL7
    • 种属Human
    • 序列MGSSHHHHHH SSGLVPRGSH MASTGQPEDD TETTGLEGGV AMPGAEDDVV TPGTSEDRYK SGLTTLVATS VNSVTGIRIE DLPTSESTVH AQEQSPSATA SNVATSHSTE KVDGDTQTTV EKDGLSTVTL
    • 分子量13 kDa including tags
    • 氨基酸23 to 131
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab117687 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    HPLC

    SDS-PAGE

  • 纯度> 95 % SDS-PAGE.
    Purity was determined to be greater than 95% as determined by RP-HPLC and SDS-PAGE.
  • 形式Liquid
  • 补充说明Although stable 4°C for 4 weeks, ab117687 should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Please see notes section.

    pH: 7.50
    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

常规信息

  • 别名
    • Aggrus
    • Glycoprotein 36 KD
    • Glycoprotein 36
    • gp 36
    • GP 38
    • GP 40
    • gp36
    • GP38
    • GP40
    • HT1A 1
    • HT1A1
    • hT1alpha 1
    • hT1alpha 2
    • hT1alpha1
    • hT1alpha2
    • Lung type I cell membrane associated glycoprotein
    • Lung type I cell membrane associated glycoprotein isoform a
    • Lung type I cell membrane associated glycoprotein T1A 2
    • OTS 8
    • OTS8
    • OTTHUMP00000009640
    • OTTHUMP00000044504
    • PA2.26
    • PA2.26 antigen
    • Pdpn
    • PDPN_HUMAN
    • Podoplanin
    • PSEC0003
    • PSEC0025
    • T1 alpha
    • T1 ALPHA GENE
    • T1-alpha
    • T1A
    • T1A 2
    • TI1A
    • TIA 2
    • TIA2
    see all
  • 功能May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels.
  • 组织特异性Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas.
  • 序列相似性Belongs to the podoplanin family.
  • 翻译后修饰Extensively O-glycosylated. Contains sialic acid residues. O-glycosylation is necessary for platelet aggregation activity.
    The N-terminus is blocked.
  • 细胞定位Membrane. Cell projection > filopodium membrane. Cell projection > lamellipodium membrane. Cell projection > microvillus membrane. Cell projection > ruffle membrane. Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles.
  • Information by UniProt

Recombinant Human Podoplanin / gp36 protein (ab117687)参考文献

ab117687 has not yet been referenced specifically in any publications.

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