This product is an active protein and may elicit a biological response in vivo, handle with caution.
Polo like Kinase 4
Polo-like kinase 4
Protein serine/threonine kinase
Serine/Threonine Kinase 18
Serine/threonine protein kinase 18
Serine/threonine protein kinase PLK4
Serine/threonine protein kinase Sak
Serine/threonine-protein kinase 18
Serine/threonine-protein kinase PLK4
Serine/threonine-protein kinase SAK
Snk Akin Kinase
功能Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Its central role in centriole replication suggests a posible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2/CHK2.
序列相似性Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. Contains 1 POLO box domain. Contains 1 protein kinase domain.
翻译后修饰Ubiquitinated; leading to its degradation by the proteasome. Tyrosine-phosphorylated by TEC.
细胞定位Cytoplasm > cytoskeleton > centrosome > centriole. Nucleus > nucleolus. Cleavage furrow. Associates with centrioles throughout the cell cycle. According to PubMed:16244668, it is not present at cleavage furrows.