Golgi associated PDZ and coiled coil motif containing
Golgi associated PDZ and coiled coil motif containing protein
Golgi-associated PDZ and coiled-coil motif-containing protein
PDZ protein interacting specifically with TC 10
PDZ protein interacting specifically with TC10
PDZ/coiled coil domain binding partner for the rho family GTPase TC 10
PDZ/coiled coil domain binding partner for the rho family GTPase TC10
Protein interacting specifically with Tc 10
Protein interacting specifically with Tc10
功能Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ACCN3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.
疾病相关Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.
序列相似性Contains 1 PDZ (DHR) domain.
结构域The PDZ domain mediates interactions with FZD5, FZD8, ACCN3, GRID2, CLCN3 (By similarity). Mediates also interaction with CFTR and ADRB1. The coiled-coil region probably mediates association to membranes, targeting to the Golgi, and interactions with GOLGA3, and STX6. May also mediate interaction with RHOQ.
细胞定位Cytoplasm. Golgi apparatus membrane. Golgi apparatus > trans-Golgi network membrane. Cell junction > synapse. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell projection > dendrite. Enriched in synaptosomal and postsynaptic densities (PSD) fractions (By similarity). Expressed in cell bodies and dendrites of Purkinje cells (By similarity). Localized at the trans-Golgi network (TGN) of spermatids and the medulla of round spermatides.