Recombinant人PINX1 protein (ab85338)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human
    • 序列MGSSHHHHHH SSGLVPRGSH MSMLAERRRK QKWAVDPQNT AWSNDDSKFG QRMLEKMGWS KGKGLGAQEH GATDHIKVQV KNNHLGLGAT INNEDNWIAH QDDFNQLLAE LNTCHGQETT DSSDKKEKKS FSLEEKSKIS KNRVHYMKFT KGKDLSSRSK TDLDCIFGKR QSKKTPEGDA SPSTPEENET TTTSAFTIQE YFAKRMAALK NKPQVPVPGS DISETQVERK RGKKINKEAT GKDVESYLQP KAKRHTEGKP ERAEAQERVA KKKSAPAEEQ LRGPCWDQSS KASAQDAGDH VQPPEGRDFT LKPKKRRGKK KLQKPVEIAE DATLEETLVK KKKKKDSK

技术指标

Our Abpromise guarantee covers the use of ab85338 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 95 % SDS-PAGE.
    ab85338 is purified using conventional chromatography techniques. Endotoxin Level: < 1.0 EU per 1 µg of protein (determined by LAL method ).
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, 20mM Tris HCl, 1mM DTT, pH 8.0

常规信息

  • 别名
    • 67-11-3 protein
    • FLJ20565
    • Hepatocellular carcinoma-related putative tumor suppressor
    • Liver-related putative tumor suppressor
    • LPTL
    • LPTS
    • MGC8850
    • OTTHUMP00000224984
    • OTTHUMP00000224985
    • OTTHUMP00000224986
    • OTTHUMP00000225053
    • OTTHUMP00000225054
    • PIN2 interacting protein 1
    • Pin2-interacting protein X1
    • PIN2/TERF1-interacting telomerase inhibitor 1
    • PINX1
    • PINX1_HUMAN
    • Protein 67-11-3
    • TRF1-interacting protein 1
    see all
  • 功能Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor.
  • 组织特异性Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines.
  • 序列相似性Belongs to the PINX1 family.
    Contains 1 G-patch domain.
  • 结构域The TID (telomerase inhibiting domain) domain is sufficient to bind TERT and inhibit its activity.
    The TBM domain mediates interaction with TERF1.
  • 细胞定位Nucleus. Nucleus > nucleolus. Chromosome > telomere. Chromosome > centromere > kinetochore. Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE.
  • Information by UniProt

Recombinant Human PINX1 protein 图像

  • 15% SDS-PAGE showing ab85338 at approximately 39.1kDa (3µg).

Recombinant Human PINX1 protein (ab85338)参考文献

ab85338 has not yet been referenced specifically in any publications.

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