Recombinant人Pik3ca + PIK3R1 protein (ab85833)

概述

  • 产品名称Recombinant人Pik3ca + PIK3R1 protein
  • 蛋白长度Full length protein

描述

  • 性质Recombinant
  • 来源Baculovirus infected Sf9 cells
  • 氨基酸序列
    • 种属Human

技术指标

Our Abpromise guarantee covers the use of ab85833 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性The Specific activity of ab85833 was determined to be 5147 RLU/min/mg.
  • 应用

    Western blot

    Functional Studies

    SDS-PAGE

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: 150mM Imidazole
    Constituents: 25% Glycerol, 50mM Sodium phosphate, 300mM Sodium chloride, 2mM DTT, 0.1mM PMSF, pH 7.0

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • 6330412C2
    • caPI3K
    • GRB1
    • MGC116320
    • MGC142161
    • MGC142163
    • MGC161268
    • OTTMUSP00000023403
    • p110
    • p110alpha
    • p50 alpha
    • p55 alpha
    • p85
    • p85 alpha
    • Phosphatidylinositol 3 kinase associated p85 alpha
    • Phosphatidylinositol 3 kinase catalytic 110 KD alpha
    • Phosphatidylinositol 3 kinase catalytic alpha polypeptide
    • Phosphatidylinositol 3 kinase regulatory 1
    • Phosphatidylinositol 3 kinase regulatory alpha subunit
    • Phosphatidylinositol 3 kinase regulatory subunit alpha
    • Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha isoform
    • Phosphoinositide 3 kinase regulatory subunit 1 (alpha)
    • Phosphoinositide 3 kinase regulatory subunit 1
    • Phosphoinositide 3 kinase regulatory subunit polypeptide 1 (p85 alpha)
    • PI3 kinase p110 subunit alpha
    • PI3 kinase p85 alpha subunit
    • PI3 kinase p85 subunit alpha
    • PI3K
    • PIK3R1
    • PtdIns 3 kinase p110
    • PtdIns 3 kinase p85 alpha
    see all
  • 相关性The enzyme phosphatidylinositol 3 kinase (PI3 kinase) is a lipid kinase that generates phosphatidylinositol 3, 4, 5-triphosphate in response to receptor activation in many signal transduction pathways. Class IA PI3Ks exist as a heterodimer of a catalytic 110 kDa (p110) and a regulatory p85 subunit (e.g. p85 alpha). p85 alpha is an adaptor molecule that regulates the activity of the catalytic p110 subunit by binding to phosphorylated receptor tyrosine kinases (RTKs) through its SH2 domain and mediating the interaction between p110 and the plasma membrane. p85 alpha is necessary for insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Four isoforms of p110 has been found; alpha, beta, gamma, and the delta subunit. The alpha isoform, also known as PI3KCA, is a transforming oncogene that was shown to have activating mutations in nine types of cancers such as colon, brain, breast and stomach.

Recombinant human Pik3ca + PIK3R1 protein 图像

  • The Specific activity of ab85833 was determined to be 5147 RLU/min/mg.
  • SDS-PAGE showing ab85833 with bands at approximately 111 (Pik3ca) and 86kDa (PIK3R1).

Recombinant human Pik3ca + PIK3R1 protein (ab85833)参考文献

ab85833 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"