Recombinant人Pik3ca + PIK3R1 protein (ab85833)

常规信息

• 别名
  • 6330412C2
  • caPI3K
  • GRB1

  • MGC116320
  • MGC142161
  • MGC142163
  • MGC161268
  • OTTMUSP00000023403
  • p110
  • p110alpha
  • p50 alpha
  • p55 alpha
  • p85
  • p85 alpha
  • Phosphatidylinositol 3 kinase associated p85 alpha
  • Phosphatidylinositol 3 kinase catalytic 110 KD alpha
  • Phosphatidylinositol 3 kinase catalytic alpha polypeptide
  • Phosphatidylinositol 3 kinase regulatory 1
  • Phosphatidylinositol 3 kinase regulatory alpha subunit
  • Phosphatidylinositol 3 kinase regulatory subunit alpha
  • Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha isoform
  • Phosphoinositide 3 kinase regulatory subunit 1 (alpha)
  • Phosphoinositide 3 kinase regulatory subunit 1
  • Phosphoinositide 3 kinase regulatory subunit polypeptide 1 (p85 alpha)
  • PI3 kinase p110 subunit alpha
  • PI3 kinase p85 alpha subunit
  • PI3 kinase p85 subunit alpha
  • PI3K
  • PIK3R1
  • PtdIns 3 kinase p110
  • PtdIns 3 kinase p85 alpha

  see all
• 相关性The enzyme phosphatidylinositol 3 kinase (PI3 kinase) is a lipid kinase that generates phosphatidylinositol 3, 4, 5-triphosphate in response to receptor activation in many signal transduction pathways. Class IA PI3Ks exist as a heterodimer of a catalytic 110 kDa (p110) and a regulatory p85 subunit (e.g. p85 alpha). p85 alpha is an adaptor molecule that regulates the activity of the catalytic p110 subunit by binding to phosphorylated receptor tyrosine kinases (RTKs) through its SH2 domain and mediating the interaction between p110 and the plasma membrane. p85 alpha is necessary for insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Four isoforms of p110 has been found; alpha, beta, gamma, and the delta subunit. The alpha isoform, also known as PI3KCA, is a transforming oncogene that was shown to have activating mutations in nine types of cancers such as colon, brain, breast and stomach.