Recombinant人PIAS3 protein (ab125996)

概述

  • 产品名称
    Recombinant人PIAS3 protein
  • 蛋白长度
    Protein fragment

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 分子量
      27 kDa
    • 氨基酸
      274 to 521

技术指标

Our Abpromise guarantee covers the use of ab125996 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 形式
    Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at -20°C.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • 复溶
    Reconstitute with water to desired concentration.

常规信息

  • 别名
    • E3 SUMO protein ligase PIAS 3
    • E3 SUMO protein ligase PIAS3
    • E3 SUMO-protein ligase PIAS3
    • FLJ14651
    • OTTHUMP00000015586
    • OTTHUMP00000015587
    • PIAS 3
    • Pias3
    • PIAS3 protein
    • PIAS3_HUMAN
    • Protein inhibitor of activated STAT 3
    • Protein inhibitor of activated STAT protein 3
    • Protein inhibitor of activated STAT3
    • Zinc finger MIZ type containing 5
    • ZMIZ 5
    • ZMIZ5
    see all
  • 功能
    Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2 which promotes its interaction with SIRT1 (PubMed:25406032). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (PubMed:24651376).
  • 组织特异性
    Widely expressed.
  • 通路
    Protein modification; protein sumoylation.
  • 序列相似性
    Belongs to the PIAS family.
    Contains 1 PINIT domain.
    Contains 1 SAP domain.
    Contains 1 SP-RING-type zinc finger.
  • 结构域
    The PINIT domain of PIAS3 is required for STAT3-PIAS3 interaction and for transloaction to the nucleus.
    The LXXLL motif is a transcriptional coregulator signature.
  • 翻译后修饰
    Sumoylated.
  • 细胞定位
    Cytoplasm. Nucleus. Nucleus speckle. Colocalizes with MITF in the nucleus. Colocalizes with GFI1 in nuclear dots. Colocalizes with SUMO1 in nuclear granules.
  • Information by UniProt

文献

ab125996 has not yet been referenced specifically in any publications.

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