Recombinant人PI4 kinase beta protein (ab105199)

概述

描述

  • 性质Recombinant
  • 来源Baculovirus infected Sf9 cells
  • 氨基酸序列
    • AccessionQ9UBF8-2
    • 种属Human
    • 分子量120 kDa including tags
    • 氨基酸1 to 801

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技术指标

Our Abpromise guarantee covers the use of ab105199 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性The Specific activity of ab105199 was determined to be 32 nmol/min/mg.
  • 应用

    SDS-PAGE

    Western blot

    Functional Studies

  • 纯度> 90 % SDS-PAGE.
    Purity was determined to be >90% by densitometry.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • DKFZp686O1820
    • FLJ30129
    • NPIK
    • Phosphatidylinositol 4 kinase beta
    • Phosphatidylinositol 4 kinase catalytic beta
    • Phosphatidylinositol 4 kinase catalytic beta polypeptide
    • Phosphatidylinositol 4 kinase wortmannin sensitive
    • Phosphatidylinositol 4-kinase beta
    • PI4K BETA
    • PI4K-beta
    • PI4K92
    • PI4KB
    • PI4KB_HUMAN
    • PI4Kbeta
    • PI4KIIIbeta
    • PIK4CB
    • PtdIns 4 kinase
    • PtdIns 4-kinase beta
    • Type III phosphatidylinositol 4 kinase beta
    see all
  • 功能Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking.
  • 组织特异性Widely expressed with highest levels in heart, skeletal muscle, pancreas, testis and ovary. Weakly expressed in liver.
  • 序列相似性Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.
    Contains 1 PI3K/PI4K domain.
    Contains 1 PIK helical domain.
  • 细胞定位Endomembrane system. Mitochondrion outer membrane. Rough endoplasmic reticulum membrane. Golgi apparatus. Cytoplasm, perinuclear region. Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) on the Golgi complex.
  • Information by UniProt

Recombinant human PI4 kinase beta protein 图像

  • The Specific activity of ab105199 was determined to be 32 nmol/min/mg.
  • SDS-PAGE showing ab105199 at approximately 120kDa.

Recombinant human PI4 kinase beta protein (ab105199)参考文献

ab105199 has not yet been referenced specifically in any publications.

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