Recombinant人PI3K p85 protein (ab123752)

概述

  • 产品名称Recombinant人PI3K p85 protein
  • 蛋白长度Full length protein

描述

  • 性质Recombinant
  • 来源Baculovirus infected Sf9 cells
  • 氨基酸序列
    • AccessionP27986
    • 种属Human
    • 分子量86 kDa including tags
    • 氨基酸1 to 724
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab123752 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 95 % SDS-PAGE.

  • 形式Liquid
  • 补充说明Centrifuge the vial prior to opening.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.00
    Preservative: 1.02% Imidazole
    Constituents: 1.75% Sodium chloride, 25% Glycerol, 0.03% DTT, 0.82% Sodium phosphate, 0.002% PMSF

常规信息

  • 别名
    • GRB 1
    • GRB1
    • p85
    • p85 alpha
    • P85A_HUMAN
    • Phosphatidylinositol 3 kinase associated p 85 alpha
    • Phosphatidylinositol 3 kinase regulatory 1
    • Phosphatidylinositol 3 kinase regulatory subunit alpha
    • Phosphatidylinositol 3 kinase regulatory subunit polypeptide 1 (p85 alpha)
    • Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha
    • Phosphatidylinositol 3-kinase regulatory subunit alpha
    • Phosphoinositide 3 kinase regulatory subunit 1
    • Phosphoinositide 3 kinase regulatory subunit 1 (alpha)
    • Phosphoinositide 3 kinase regulatory subunit 1 (p85 alpha)
    • Phosphoinositide 3 kinase regulatory subunit polypeptide 1 (p85 alpha)
    • PI3 kinase p85 subunit alpha
    • PI3-kinase regulatory subunit alpha
    • PI3-kinase subunit p85-alpha
    • PI3K
    • PI3K regulatory subunit alpha
    • Pik3r1
    • PtdIns 3 kinase p85 alpha
    • PtdIns-3-kinase regulatory subunit alpha
    • PtdIns-3-kinase regulatory subunit p85-alpha
    see all
  • 功能Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.
  • 组织特异性Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level).
  • 序列相似性Belongs to the PI3K p85 subunit family.
    Contains 1 Rho-GAP domain.
    Contains 2 SH2 domains.
    Contains 1 SH3 domain.
  • 结构域The SH3 domain mediates the binding to CBLB, and to HIV-1 Nef.
  • 翻译后修饰Polyubiquitinated in T-cells by CBLB; which does not promote proteasomal degradation but impairs association with CD28 and CD3Z upon T-cell activation.
    Phosphorylated. Dephosphorylated by PTPRJ.
  • Information by UniProt

Recombinant Human PI3K p85 protein 图像

  • SDS-PAGE showing ab123752 at approximately 86kDa.

Recombinant Human PI3K p85 protein (ab123752)参考文献

ab123752 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab123752.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"