Recombinant人PI 4 Kinase type 2 beta protein (ab105202)

概述

  • 产品名称Recombinant人PI 4 Kinase type 2 beta protein
  • 蛋白长度Full length protein

描述

  • 性质Recombinant
  • 来源Baculovirus infected Sf9 cells
  • 氨基酸序列
    • AccessionQ8TCG2
    • 种属Human
    • 分子量84 kDa including tags
    • 氨基酸1 to 481

技术指标

Our Abpromise guarantee covers the use of ab105202 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性The Specific activity of ab105202 was determined to be 218 nmol/min/mg.
  • 应用

    SDS-PAGE

    Western blot

    Functional Studies

  • 纯度> 90 % SDS-PAGE.
    Purity was determined to be >90% by densitometry.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • 2610042N09Rik
    • 4933409G22Rik
    • FLJ11105
    • P4K2B_HUMAN
    • Phosphatidylinositol 4 kinase type 2 beta
    • Phosphatidylinositol 4 kinase type II beta
    • Phosphatidylinositol 4-kinase type 2-beta
    • Phosphatidylinositol 4-kinase type II-beta
    • PI4K 2 beta
    • PI4K 2b
    • PI4K II beta
    • PI4K IIb
    • Pi4k2b
    • PI4KII-BETA
    • PI4KIIb
    • PIK42B
    • Type II phosphatidylinositol 4 kinase beta isoform
    see all
  • 功能Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking.
  • 组织特异性Widely expressed.
  • 序列相似性Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
    Contains 1 PI3K/PI4K domain.
  • 细胞定位Cytoplasm. Membrane. Mostly cytoplasmic but also found associated with the plasma membrane, the Golgi and endosomes. Compared to PI4K2A, a larger fraction of PI4K2B is cytosolic due to a smaller extent of palmitoylation. Translocates to membranes where it is recruited by PDGF stimulation by a Rac-GTP-dependent mechanism.
  • Information by UniProt

Recombinant human PI 4 Kinase type 2 beta protein 图像

  • The Specific activity of ab105202 was determined to be 218 nmol/min/mg.
  • SDS-PAGE showing ab105202 at approximately 84kDa.

Recombinant human PI 4 Kinase type 2 beta protein (ab105202)参考文献

ab105202 has not yet been referenced specifically in any publications.

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