来源 Baculovirus infected Sf9 cells
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
纯度 > 95
% SDS-PAGE. Affinity purified.
The PI 3 Kinase catalytic subunit gamma D946A protein is a catalytically inactive mutant of PI 3 Kinase with a D946A mutation in the ATP binding site.
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Constituents: 50% Glycerol, 50mM Sodium chloride, 25mM Tris HCl, 0.5mM Magnesium chloride, pH 8.0
1 phosphatidylinositol 3 kinase
5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma
5-bisphosphate 3-kinase catalytic subunit gamma isoform
功能 3-phosphorylates the cellular phosphoinositide PtdIns-4,5-biphosphate (PtdIns(4,5)P2) to produce PtdIns-3, 4,5-triiphosphate (PtdIns(3,4,5)P3). Links G-protein coupled receptor activation to the secondary messenger PtdIns(3,4,5)P3 production.
组织特异性 Pancreas, skeletal muscle, liver and heart.
通路 Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.
序列相似性 Belongs to the PI3/PI4-kinase family. Contains 1 PI3K/PI4K domain.
Information by UniProt
Recombinant Human PI 3 Kinase catalytic subunit gamma (mutated D946 A) protein (ab91392)参考文献
has not yet been referenced specifically in any publications.
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