Recombinant人Phospholipase A2 protein (ab112338)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP47712
    • 种属Human
    • 序列MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFI STTPDSRKRTRHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDE TLGTATFTVS
    • 分子量38 kDa including tags
    • 氨基酸1 to 110
    • 标签GST tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab112338 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    ELISA

    Western blot

  • 形式Liquid
  • 补充说明Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • Calcium dependent phospholipid binding protein
    • CPLA 2
    • cPLA2
    • cPLA2 alpha
    • Cytosolic phospholipase A2
    • Cytosolic phospholipase A2 group IVA
    • Lysophospholipase
    • MGC126350
    • PA24A_HUMAN
    • Phosphatidylcholine 2 acylhydrolase
    • Phosphatidylcholine 2-acylhydrolase
    • Phospholipase A2 group 4 A
    • Phospholipase A2 group IVA
    • Phospholipase A2 group IVA (cytosolic calcium dependent)
    • PhospholipaseA2
    • PLA2G4
    • pla2g4a
    see all
  • 功能Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
  • 组织特异性Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium.
  • 序列相似性Contains 1 C2 domain.
    Contains 1 PLA2c domain.
  • 结构域The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+).
  • 翻译后修饰Activated by phosphorylation at both Ser-505 and Ser-727.
  • 细胞定位Cytoplasm. Cytoplasmic vesicle. Translocates to membrane vesicles in a calcium-dependent fashion.
  • Information by UniProt

Recombinant Human Phospholipase A2 protein 图像

  • ab112338 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

Recombinant Human Phospholipase A2 protein (ab112338)参考文献

ab112338 has not yet been referenced specifically in any publications.

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