Recombinant人Phospholamban protein (ab114227)

概述

  • 产品名称Recombinant人Phospholamban protein
  • 蛋白长度Protein fragment

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP26678
    • 种属Human
    • 序列MEKVQYLTRSAIRRASTIEMPQQARQKLQN
    • 分子量29 kDa including tags
    • 氨基酸1 to 30

技术指标

Our Abpromise guarantee covers the use of ab114227 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • Cardiac phospholamban
    • CMD1P
    • CMH18
    • PLB
    • Pln
    • PPLA_HUMAN
    see all
  • 功能Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.
  • 组织特异性Heart muscle (at protein level).
  • 疾病相关Cardiomyopathy, dilated 1P
    Cardiomyopathy, familial hypertrophic 18
  • 序列相似性Belongs to the phospholamban family.
  • 翻译后修饰Phosphorylation by PKA abolishes the inhibition of ATP2A2-mediated calcium uptake. Phosphorylated at Thr-17 by CaMK2, and in response to beta-adrenergic stimulation. Phosphorylation by DMPK may stimulate sarcoplasmic reticulum calcium uptake in cardiomyocytes.
  • 细胞定位Endoplasmic reticulum membrane. Sarcoplasmic reticulum membrane. Mitochondrion membrane. Membrane. Colocalizes with HAX1 at the endoplasmic reticulum (PubMed:17241641). Colocalizes with DMPK a the sarcoplasmic reticulum (PubMed:15598648).
  • Information by UniProt

Recombinant Human Phospholamban protein 图像

  • ab114227 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

Recombinant Human Phospholamban protein (ab114227)参考文献

ab114227 has not yet been referenced specifically in any publications.

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