Recombinant人PHLPP2 protein (ab125556)

概述

  • 产品名称Recombinant人PHLPP2 protein
  • 蛋白长度Protein fragment

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ6ZVD8
    • 种属Human
    • 分子量56 kDa including tags
    • 氨基酸766 to 1043

技术指标

Our Abpromise guarantee covers the use of ab125556 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    SDS-PAGE

  • 纯度> 95 % Densitometry.
    ab125556 is >95% pure.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.88% Sodium chloride

常规信息

  • 别名
    • KIAA0931
    • PH domain and leucine rich repeat protein phosphatase 2
    • PH domain leucine rich repeat protein phosphatase like
    • PH domain leucine-rich repeat-containing protein phosphatase 2
    • PH domain leucine-rich repeat-containing protein phosphatase-like
    • PHLP2_HUMAN
    • PHLPP like
    • PHLPP-like
    • Phlpp2
    • PHLPPL
    see all
  • 功能Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor.
  • 组织特异性In colorectal cancer tissue, expression is highest in the surface epithelium of normal colonic mucosa adjacent to the cancer tissue but is largely excluded from the crypt bases. Expression is lost or significantly decreased in 80% of tested tumors (at protein level).
  • 序列相似性Contains 22 LRR (leucine-rich) repeats.
    Contains 1 PH domain.
    Contains 1 PP2C-like domain.
  • 细胞定位Cytoplasm. Membrane. Nucleus. In colorectal cancer tissue, expression is concentrated in the cytoplasm and nucleus.
  • Information by UniProt

Recombinant Human PHLPP2 protein 图像

  • SDS PAGE analysis of ab125556 (PHLPP2 protein).

Recombinant Human PHLPP2 protein (ab125556)参考文献

ab125556 has not yet been referenced specifically in any publications.

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