Recombinant人PGAM2 protein (ab123178)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MGSSHHHHHH SSGLVPRGSH MATHRLVMVR HGESTWNQEN RFCGWFDAEL SEKGTEEAKR GAKAIKDAKM EFDICYTSVL KRAIRTLWAI LDGTDQMWLP VVRTWRLNER HYGGLTGLNK AETAAKHGEE QVKIWRRSFD IPPPPMDEKH PYYNSISKER RYAGLKPGEL PTCESLKDTI ARALPFWNEE IVPQIKAGKR VLIAAHGNSL RGIVKHLEGM SDQAIMELNL PTGIPIVYEL NKELKPTKPM QFLGDEETVR KAMEAVAAQG KAK
    • 分子量
      31 kDa including tags
    • 氨基酸
      1 to 253
    • 标签
      His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab123178 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Mass Spectrometry

    SDS-PAGE

  • 质谱法
    MALDI-TOF
  • 纯度
    > 95 % SDS-PAGE.
    ab123178 is purified using conventional chromatography.
  • 形式
    Liquid
  • 补充说明
    BRENDA (Enzyme Commission number) EC=3.1.3.13; EC=5.4.2.1; EC=5.4.2.4.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Information available upon request.

常规信息

  • 别名
    • BPG dependent PGAM 2
    • BPG-dependent PGAM 2
    • GSD10
    • MGC88743
    • Muscle specific phosphoglycerate mutase
    • Muscle-specific phosphoglycerate mutase
    • OTTHUMP00000207787
    • PGAM 2
    • PGAM M
    • PGAM-M
    • Pgam2
    • PGAM2_HUMAN
    • PGAMM
    • Phosphoglycerate mutase 2
    • phosphoglycerate mutase 2 (muscle)
    • Phosphoglycerate mutase isozyme M
    see all
  • 功能
    Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity.
  • 组织特异性
    In mammalian tissues there are two types of phosphoglycerate mutase isozymes: type-M in muscles and type-B in other tissues.
  • 疾病相关
    Defects in PGAM2 are the cause of glycogen storage disease type 10 (GSD10) [MIM:261670]. A metabolic disorder characterized by myoglobinuria, increased serum creatine kinase levels, decreased phosphoglycerate mutase activity, myalgia, muscle pain, muscle cramps and excercise intolerance.
  • 序列相似性
    Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
  • Information by UniProt

图片

  • 15% SDS-PAGE analysis of ab123178 (3ug)

文献

ab123178 has not yet been referenced specifically in any publications.

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