Recombinant人PER2 protein (ab112382)

概述

  • 产品名称Recombinant人PER2 protein
  • 蛋白长度Protein fragment

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionO15055
    • 种属Human
    • 序列MNGYAEFPPSPSNPTKEPVEPQPSQVPLQEDVDMSSGSSGHETNENCSTG RDSQGSDCDDSGKELGMLVEPPDARQSPDTFSLMMAKSEHNPSTSGCSSD
    • 分子量37 kDa including tags
    • 氨基酸1 to 100

技术指标

Our Abpromise guarantee covers the use of ab112382 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性Useful for Antibody Production and Protein Array
  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明ab112382 is best used within three months from the date of receiptUseful for Antibody Production and Protein Array
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione
    Note: Glutathione is reduced

常规信息

  • 别名
    • Circadian clock protein PERIOD 2
    • FASPS
    • FASPS1
    • hPER 2
    • hPER2
    • KIAA0347
    • OTTHUMP00000164476
    • PER 2
    • PER2
    • PER2_HUMAN
    • Period 2
    • Period 2 isoform 1
    • Period circadian clock 2
    • Period circadian protein 2
    • Period circadian protein homolog 2
    • Period homolog 2
    • Period homolog 2 (Drosophila)
    • Period, Drosophila, homolog of, 2
    • Period2
    see all
  • 功能Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK
    NPAS2-BMAL1
    BMAL2-induced transactivation.
  • 组织特异性Widely expressed. Found in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. High levels in skeletal muscle and pancreas. Low level in lung.
  • 疾病相关Defects in PER2 are a cause of familial advanced sleep-phase syndrome (FASPS) [MIM:604348]. FASPS is characterized by very early sleep onset and offset. Individuals are 'morning larks' with a 4 hours advance of the sleep, temperature and melatonin rhythms.
  • 序列相似性Contains 1 PAC (PAS-associated C-terminal) domain.
    Contains 2 PAS (PER-ARNT-SIM) domains.
  • 翻译后修饰Phosphorylated by CSNK1E and CSNK1D. Phosphorylation results in PER2 protein degradation.
  • 细胞定位Nucleus. Cytoplasm. Mainly nuclear. Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Retention of PER1 in the cytoplasm occurs through PER1-PER2 heterodimer formation or by interaction with CSNK1E and/or phosphorylation which appears to mask the PER nuclear localization signal. Also translocated to the nucleus by CRY1 or CRY2.
  • Information by UniProt

Recombinant Human PER2 protein 图像

  • ab112382 analysed by 12.5% SDS-PAGE and stained with Coomassie Blue.

Recombinant Human PER2 protein (ab112382)参考文献

ab112382 has not yet been referenced specifically in any publications.

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