The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
生物活性ab86705 contains a natural variant M72T.
补充说明ab86705 contains a natural variant M72T.
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Constituents: 20% Glycerol, 20mM Tris HCl, pH 8.0
Cell proliferation-inducing gene 35 protein
Pigment epithelium derived factor
Pigment epithelium-derived factor
Proliferation inducing protein 35
serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
Serpin family F member 1
Serpin peptidase inhibitor clade F member 1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
功能Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
组织特异性Retinal pigment epithelial cells and blood plasma.
序列相似性Belongs to the serpin family.
发展阶段Expressed in quiescent cells.
结构域The N-terminal (AA 44-121) exhibits neurite outgrowth-inducing activity. The C-terminal exposed loop (AA 382-418) is essential for serpin activity.
翻译后修饰The N-terminus is blocked. Extracellular phosphorylation enhances antiangiogenic activity. N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.
细胞定位Secreted. Melanosome. Enriched in stage I melanosomes.