Recombinant人PEA15 protein (ab117660)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ15121
    • 种属Human
    • 序列MAEYGTLLQD LTNNITLEDL LKSACKED IPSEKSEEIT TGSAWFSFLE HNKLDKDNL SYIEHIFEIS RRPDLLTMVV DYRTRVLKIS EDELDTKLT RIPSAKKYKD IIRQPSEEEI IKLAPPPKKA
    • 分子量15 kDa
    • 氨基酸1 to 130

技术指标

Our Abpromise guarantee covers the use of ab117660 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 90 % SDS-PAGE.

  • 形式Liquid
  • 补充说明For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term.

    pH: 7.50
    Constituents: 0.32% Tris HCl, 0.02% DTT, 10% Glycerol

常规信息

  • 别名
    • 15 kDa phosphoprotein enriched in astrocytes
    • Astrocytic phosphoprotein PEA 15
    • Astrocytic phosphoprotein PEA-15
    • Astrocytic phosphoprotein PEA15
    • HMAT 1
    • HMAT1
    • Homolog of mouse MAT 1 oncogene
    • Homolog of mouse MAT1 oncogene
    • HUMMAT 1H
    • HUMMAT1H
    • MAT 1
    • MAT 1H
    • MAT1
    • MAT1H
    • PEA 15
    • Pea15
    • PEA15 protein
    • PEA15_HUMAN
    • PED
    • Phosphoprotein enriched in astrocytes 15
    • Phosphoprotein enriched in astrocytes 15kD
    • Phosphoprotein enriched in diabetes
    see all
  • 功能Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.
  • 组织特异性Ubiquitously expressed. Most abundant in tissues such as heart, brain, muscle and adipose tissue which utilize glucose as an energy source. Lower expression in glucose-producing tissues. Higher levels of expression are found in tissues from individuals with type 2 diabetes than in controls.
  • 序列相似性Contains 1 DED (death effector) domain.
  • 翻译后修饰Phosphorylated by protein kinase C and calcium-calmodulin-dependent protein kinase. These phosphorylation events are modulated by neurotransmitters or hormones.
  • 细胞定位Cytoplasm. Associated with microtubules.
  • Information by UniProt

Recombinant Human PEA15 protein (ab117660)参考文献

ab117660 has not yet been referenced specifically in any publications.

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