Recombinant人PDX1 protein (ab114175)

概述

  • 产品名称Recombinant人PDX1 protein
  • 蛋白长度Full length protein

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP52945
    • 种属Human
    • 序列MNGEEQYYAATQLYKDPCAFQRGPAPEFSASPPACLYMGRQPPPPPPHPF PGALGALEQGSPPDISPYEVPPLADDPAVAHLHHHLPAQLALPHPPAGPF PEGAEPGVLEEPNRVQLPFPWMKSTKAHAWKGQWAGGAYAAEPEENKRTR TAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLTERHIKIWFQNRRMK WKKEEDKKRGGGTAVGGGGVAEPEQDCAVTSGEELLALPPPPPPGGAVPP AAPVAAREGRLPPGLSASPQPSSVAPRRPQEPR
    • 分子量58 kDa including tags
    • 氨基酸1 to 283

技术指标

Our Abpromise guarantee covers the use of ab114175 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Western blot

    ELISA

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

常规信息

  • 别名
    • Glucose sensitive factor
    • Glucose-sensitive factor
    • GSF
    • IDX 1
    • IDX-1
    • IDX1
    • Insulin promoter factor 1
    • Insulin promoter factor 1 homeodomain transcription factor
    • Insulin upstream factor 1
    • IPF 1
    • IPF-1
    • IPF1
    • Islet/duodenum homeobox 1
    • Islet/duodenum homeobox-1
    • IUF 1
    • IUF-1
    • IUF1
    • MODY4
    • Pancreas/duodenum homeobox 1
    • Pancreas/duodenum homeobox protein 1
    • pancreatic and duodenal homeobox P
    • PDX 1
    • PDX-1
    • PDX1
    • PDX1_HUMAN
    • Somatostatin transactivating factor 1
    • Somatostatin-transactivating factor 1
    • STF 1
    • STF-1
    • STF1
    see all
  • 功能Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.
  • 组织特异性Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells).
  • 疾病相关Defects in PDX1 are a cause of pancreatic agenesis (PAC) [MIM:260370]. This autosomal recessive disorder is characterized by absence or hypoplasia of pancreas, leading to early-onset insulin-dependent diabetes mellitus. This was found in a frameshift mutation that produces a truncated protein and results in a second initiation that produces a second protein that act as a dominant negative mutant.
    Defects in PDX1 are a cause of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853]; also known as diabetes mellitus type 2. NIDDM is characterized by an autosomal dominant mode of inheritance, onset during adulthood and insulin resistance.
    Defects in PDX1 are the cause of maturity-onset diabetes of the young type 4 (MODY4) [MIM:606392]; also symbolized MODY-4. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
  • 序列相似性Belongs to the Antp homeobox family. IPF1/XlHbox-8 subfamily.
    Contains 1 homeobox DNA-binding domain.
  • 结构域The Antp-type hexapeptide mediates heterodimerization with PBX on a regulatory element of the somatostatin promoter.
    The homeodomain, which contains the nuclear localization signal, not only mediates DNA-binding, but also acts as a protein-protein interaction domain for TCF3(E47), NEUROD1 and HMG-I(Y).
  • 翻译后修饰Phosphorylated by the SAPK2 pathway at high intracellular glucose concentration.
  • 细胞定位Nucleus.
  • Information by UniProt

Recombinant Human PDX1 protein 图像

  • ab114175 on a 12.5% SDS-PAGE Stained with Coomassie Blue.

Recombinant Human PDX1 protein (ab114175)参考文献

ab114175 has not yet been referenced specifically in any publications.

Product Wall

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