Recombinant人PDGF Receptor alpha (mutated T674 I) protein (ab119720)

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概述

描述

  • 性质Recombinant
  • 来源Baculovirus infected Sf9 cells
  • 氨基酸序列
    • AccessionP16234
    • 种属Human
    • 分子量95 kDa including tags
    • 氨基酸550 to 1089

技术指标

Our Abpromise guarantee covers the use of ab119720 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性The specific activity of ab119720 was determined to be 20 nmol/min/mg.
  • 应用

    Western blot

    Functional Studies

    SDS-PAGE

  • 纯度> 80 % SDS-PAGE.
    The purity was determined to be 80% by densitometry
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 25% Glycerol, 0.79% Tris HCl, 0.88% Sodium chloride, 0.31% Glutathione, 0.003% EDTA, 0.003% DTT, 0.002% PMSF

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • Alpha-type platelet-derived growth factor receptor
    • CD140 antigen-like family member A
    • CD140a
    • CD140a antigen
    • MGC74795
    • PDGF alpha chain
    • PDGF-R-alpha
    • PDGFR 2
    • PDGFR alpha
    • PDGFR2
    • PDGFRA
    • PDGFRA/BCR fusion
    • PGFRA_HUMAN
    • Platelet derived growth factor receptor
    • Platelet derived growth factor receptor 2
    • Platelet derived growth factor receptor alpha
    • Platelet derived growth factor receptor alpha polypeptide
    • Rearranged in hypereosinophilia platelet derived growth factor receptor alpha fusion protein
    • RHEPDGFRA
    see all
  • 功能Receptor that binds both PDGFA and PDGFB and has a tyrosine-protein kinase activity.
  • 组织特异性Expressed in primary and metastatic colon tumors and in normal colon tissue. Tumors may express a different isoform to that found in normal tissue.
  • 疾病相关Note=A chromosomal aberration involving PDGFRA is found in some cases of hypereosinophilic syndrome. Interstitial chromosomal deletion del(4)(q12q12) causes the fusion of FIP1L1 and PDGFRA (FIP1L1-PDGFRA).
  • 序列相似性Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
    Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 protein kinase domain.
  • 细胞定位Membrane.
  • Information by UniProt

Recombinant human PDGF Receptor alpha (mutated T674 I) protein 图像

  • Functional Studies - PDGF Receptor alpha protein (Mutated T674 I) (ab119720)
    Functional Studies - PDGF Receptor alpha protein (Mutated T674 I) (ab119720)
    The specific activity of ab119720 was determined to be 20 nmol/min/mg
  • SDS-PAGE - PDGF Receptor alpha protein (Mutated T674 I) (ab119720)
    SDS-PAGE - PDGF Receptor alpha protein (Mutated T674 I) (ab119720)
    SDS Page analysis of ab119720

Recombinant human PDGF Receptor alpha (mutated T674 I) protein (ab119720)参考文献

ab119720 has not yet been referenced specifically in any publications.

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