Recombinant人PDGF Receptor alpha (mutated T674 I) protein (ab119720)

概述

描述

  • 性质
    Recombinant
  • 来源
    Baculovirus infected Sf9 cells
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 分子量
      95 kDa including tags
    • 氨基酸
      550 to 1089

技术指标

Our Abpromise guarantee covers the use of ab119720 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性
    The specific activity of ab119720 was determined to be 20 nmol/min/mg.
  • 应用

    Western blot

    Functional Studies

    SDS-PAGE

  • 纯度
    > 80 % SDS-PAGE.
    The purity was determined to be 80% by densitometry
  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 25% Glycerol, 0.79% Tris HCl, 0.88% Sodium chloride, 0.31% Glutathione, 0.003% EDTA, 0.003% DTT, 0.002% PMSF

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • Alpha-type platelet-derived growth factor receptor
    • CD140 antigen-like family member A
    • CD140a
    • CD140a antigen
    • MGC74795
    • PDGF alpha chain
    • PDGF-R-alpha
    • PDGFR 2
    • PDGFR alpha
    • PDGFR2
    • PDGFRA
    • PDGFRA/BCR fusion
    • PGFRA_HUMAN
    • Platelet derived growth factor receptor
    • Platelet derived growth factor receptor 2
    • Platelet derived growth factor receptor alpha
    • Platelet derived growth factor receptor alpha polypeptide
    • Rearranged in hypereosinophilia platelet derived growth factor receptor alpha fusion protein
    • RHEPDGFRA
    see all
  • 功能
    Receptor that binds both PDGFA and PDGFB and has a tyrosine-protein kinase activity.
  • 组织特异性
    Expressed in primary and metastatic colon tumors and in normal colon tissue. Tumors may express a different isoform to that found in normal tissue.
  • 疾病相关
    Note=A chromosomal aberration involving PDGFRA is found in some cases of hypereosinophilic syndrome. Interstitial chromosomal deletion del(4)(q12q12) causes the fusion of FIP1L1 and PDGFRA (FIP1L1-PDGFRA).
  • 序列相似性
    Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
    Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 protein kinase domain.
  • 细胞定位
    Membrane.
  • Information by UniProt

图片

  • The specific activity of ab119720 was determined to be 20 nmol/min/mg
  • SDS Page analysis of ab119720

文献

ab119720 has not yet been referenced specifically in any publications.

客户评价及客户问答

There are currently no Customer reviews or Questions for ab119720.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

注册