功能Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.
组织特异性Expressed in all tissues examined (testis, brain, small intestine, skeletal muscle, heart, lung, thymus, spleen, placenta, kidney, liver, pancreas, ovary and prostate) except blood. Highest levels in brain, heart, kidney, spleen, prostate and colon. Isoform PDE9A12 is found in prostate.
序列相似性Belongs to the cyclic nucleotide phosphodiesterase family. PDE9 subfamily.
结构域Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain.