Recombinant人PDE8A protein (ab114643)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionO60658
    • 种属Human
    • 序列RLPQGQKTAALPRTRGAGLLESELRDGSGKKVAVADVQFGPMRFHQDQLQ VLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACFL
    • 分子量36 kDa including tags
    • 氨基酸32 to 121

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技术指标

Our Abpromise guarantee covers the use of ab114643 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    This protein is best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • 5''-cyclic phosphodiesterase 8A
    • cAMP specific cyclic nucleotide phosphodiesterase 8A
    • FLJ16150
    • High affinity cAMP specific and IBMX insensitive 3'5' cyclic phosphodiesterase 8A
    • High affinity cAMP-specific and IBMX-insensitive 3''
    • HsT19550
    • PDE 8A
    • PDE8A
    • PDE8A_HUMAN
    • Phosphodiesterase 8A
    • Phosphodiesterase8A
    • Weakly similar to 3'5' cyclic nucleotide phosphodiesterase
    see all
  • 功能Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.
  • 组织特异性Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon.
  • 通路Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
  • 序列相似性Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
    Contains 1 PAC (PAS-associated C-terminal) domain.
    Contains 1 PAS (PER-ARNT-SIM) domain.
  • 结构域Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain.
  • Information by UniProt

Recombinant Human PDE8A protein 图像

  • 12.5% SDS-PAGE image showing ab114643 Stained with Coomassie Blue.

Recombinant Human PDE8A protein (ab114643)参考文献

ab114643 has not yet been referenced specifically in any publications.

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