Recombinant人PDE6C protein (ab125587)

概述

描述

  • 性质Recombinant
  • 来源Baculovirus infected Sf9 cells
  • 氨基酸序列
    • AccessionP51160
    • 种属Human
    • 分子量125 kDa including tags
    • 氨基酸1 to 858

技术指标

Our Abpromise guarantee covers the use of ab125587 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    SDS-PAGE

  • 纯度> 75 % Densitometry.
    Purity was determined to be >75% by densitometry.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.29% Sodium chloride

常规信息

  • 别名
    • 5''-cyclic phosphodiesterase subunit alpha''
    • cGMP phosphodiesterase 6C
    • COD4
    • Cone cGMP specific 3' 5' cyclic phosphodiesterase subunit alpha'
    • Cone cGMP-specific 3''
    • PDE 6C
    • PDE6 alpha prime
    • PDE6 alpha'
    • PDE6C
    • PDE6C_HUMAN
    • PDEA2
    • Phosphodiesterase 6C cGMP specific cone alpha prime
    see all
  • 疾病相关Defects in PDE6C are the cause of cone dystrophy type 4 (COD4) [MIM:613093]. An early-onset cone dystrophy. Cone dystrophies are retinal dystrophies characterized by progressive degeneration of the cone photoreceptors with preservation of rod function, as indicated by electroretinogram. However, some rod involvement may be present in some cone dystrophies, particularly at late stage. Affected individuals suffer from photophobia, loss of visual acuity, color vision and central visual field. Another sign is the absence of macular lesions for many years. Cone dystrophies are distinguished from the cone-rod dystrophies in which some loss of peripheral vision also occurs.
  • 序列相似性Belongs to the cyclic nucleotide phosphodiesterase family.
    Contains 2 GAF domains.
  • 细胞定位Cell membrane.
  • Information by UniProt

Recombinant Human PDE6C protein 图像

  • SDS Page analysis of ab125587

Recombinant Human PDE6C protein (ab125587)参考文献

ab125587 has not yet been referenced specifically in any publications.

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