Recombinant人PDE6 beta protein (ab125593)

概述

描述

  • 性质Recombinant
  • 来源Baculovirus infected Sf9 cells
  • 氨基酸序列
    • AccessionP35913
    • 种属Human
    • 分子量124 kDa including tags
    • 氨基酸1 to 854

技术指标

Our Abpromise guarantee covers the use of ab125593 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性The specific activity of ab125593 was determined to be 19 nmol/min/mg.
  • 应用

    Functional Studies

    SDS-PAGE

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.88% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • 5''-cyclic phosphodiesterase subunit beta
    • Congenital stationary night blindness 3 autosomal dominant
    • CSNB 3
    • CSNB3
    • CSNBAD2
    • GMP PDE beta
    • GMP-PDE beta
    • PDE 6 beta
    • PDE 6B
    • PDE6B
    • PDE6B_HUMAN
    • PDEB
    • Phosphodiesterase 6B
    • Phosphodiesterase 6B cGMP specific rod beta
    • Rd 1
    • Rd1
    • Rod cGMP phosphodiesterase beta subunit
    • Rod cGMP specific 3' 5' cyclic phosphodiesterase beta subunit
    • Rod cGMP-specific 3''
    • RP40
    see all
  • 功能This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme.
  • 疾病相关Defects in PDE6B are the cause of retinitis pigmentosa type 40 (RP40) [MIM:613801]. RP40 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
    Defects in PDE6B are a cause of congenital stationary night blindness autosomal dominant type 2 (CSNBAD2) [MIM:163500]; also known as congenital stationary night blindness Rambusch type. Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision.
  • 序列相似性Belongs to the cyclic nucleotide phosphodiesterase family.
    Contains 2 GAF domains.
  • 细胞定位Membrane.
  • Information by UniProt

Recombinant human PDE6 beta protein 图像

  • SDS Page analysis of ab125593
  • The specific activity of ab125593 was determined to be 19 nmol/min/mg.

Recombinant human PDE6 beta protein (ab125593)参考文献

ab125593 has not yet been referenced specifically in any publications.

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