This product is an active protein and may elicit a biological response in vivo, handle with caution.
5''-cyclic phosphodiesterase 10A
cAMP and cAMP inhibited cGMP 3'5' cyclic phosphodiesterase 10A
cAMP and cAMP-inhibited cGMP 3''
功能Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.
组织特异性Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum.
序列相似性Belongs to the cyclic nucleotide phosphodiesterase family. Contains 2 GAF domains.
结构域The tandem GAF domains bind cAMP, and regulate enzyme activity. The binding of cAMP stimulates enzyme activity. Composed of a C-terminal catalytic domain containing two divalent metal sites and an N-terminal regulatory domain which contains one cyclic nucleotide-binding region.
细胞定位Cytoplasm. Located mostly to soluble cellular fractions.