Recombinant人PCM1 protein (ab114699)

概述

  • 产品名称
    Recombinant人PCM1 protein
  • 蛋白长度
    Full length protein

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • 种属
      Human
    • 序列
      MATGGGPFEDGMNDQDLPNWSNENVDDRLNNMDWGAQQKKANRSSEKNKK KFGVESDKRVTNDISPESSPGVGRRRTKTPHTFPHSRYMSQMSVPEQAEL EKLKQRINFSDLDQRSIGSDSQGRATAANNKRQLSENRKPFNFLPMQINT NKSKDASTSPPNRETIGSAQCKELFASALSNDLLQNCQVSEEDGRGEPAM ESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQE KSYMKFLKKILARENEEEDVRTIDSAVGSGSVAESTSLNIDVQSEASDTT ARDPQQEPMEEIENLKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAE QAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPAV PDNRRQAESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMD KLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGLAPVVNGESNSL TSSVPYPTASLVSQNESENEGHLNPSEKLQ
    • 分子量
      84 kDa including tags
    • 氨基酸
      1 to 530

技术指标

Our Abpromise guarantee covers the use of ab114699 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • hPCM-1
    • PCM-1
    • pcm1
    • PCM1_HUMAN
    • Pericentriolar material 1
    • Pericentriolar material 1 protein
    • PTC4
    see all
  • 功能
    Required for centrosome assembly and function. Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome. Involved in the biogenesis of cilia.
  • 组织特异性
    Expressed in blood, bone marrow, breast, lymph node, ovary and thyroid.
  • 疾病相关
    Defects in PCM1 are a cause of thyroid papillary carcinoma (TPC) [MIM:188550]. TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=A chromosomal aberration involving PCM1 is found in thyroid papillary carcinomas. Translocation t(8;10)(p21.3;q11.2) with RET links the protein kinase domain of RET to the major portion of PCM1.
    Note=A chromosomal aberration involving PCM1 is found in a variety of hematological malignancies including atypical chronic myeloid leukemia (atypical CML) and T-cell lymphoma. Translocation t(8;9)(p22;p24) with JAK2 links the protein kinase domain of JAK2 to the major portion of PCM1.
  • 序列相似性
    Belongs to the PCM1 family.
  • 翻译后修饰
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位
    Cytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > centrosome. Cytoplasmic granule. Localizes to cytoplasmic granules which are enriched around the centrosome. This centrosomal enrichment requires microtubules and dynein. The majority of the protein dissociates from the centrosome during metaphase and subsequently localizes to the cleavage site in telophase.
  • Information by UniProt

图片

  • 12.5% SDS-PAGE showing ab114699 at approximately 84.41 kDa stained with Coomassie Blue.

文献

ab114699 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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