The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
补充说明Protein concentration is above or equal to 0.05 mg/ml. This protein is best used within three months from the date of receipt.
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Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.79% Tris HCl, 0.3% Glutathione
Heterogeneous nuclear ribonucleoprotein E2
Heterogenous nuclear ribonucleoprotein E2
poly(rC) binding protein 2
Poly(rC)-binding protein 2
Putative heterogeneous nuclear ribonucleoprotein X
rCbinding protein 2
功能Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling. It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitinationa and degradation.
组织特异性Detected in all tissues examined.
序列相似性Contains 3 KH domains.
翻译后修饰Phosphorylated. The non-phosphorylated form(s) exhibited the strongest poly(rC)-binding activity.
细胞定位Nucleus. Cytoplasm. Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm.