Recombinant人PAX8 protein (ab112376)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ06710
    • 种属Human
    • 序列MPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQ LRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQ N PTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDS CVA TKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPGSD KRKMD DSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFER QHYPEAY ASPSHTKGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLS THQTYPVVA DPHSPFAIKQETPEVSSSSSTPSSLSSSAFLDLQQVGSG VPPFNAFPHAA SVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGSY ASSAIAGMVAGSE YSGNAYGHTPYSSYSEAWRFPNSSLLSSPYYYSST SRPSAPPTTATAFDH L
    • 分子量75 kDa including tags
    • 氨基酸1 to 451

技术指标

Our Abpromise guarantee covers the use of ab112376 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性useful for Antibody Production and Protein Array
  • 应用

    Western blot

    ELISA

    SDS-PAGE

  • 形式Liquid
  • 补充说明ab112376 is best used within three months from the date of receipt.useful for Antibody Production and Protein Array
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione
    Note: Glutathione is reduced

常规信息

  • 别名
    • OTTHUMP00000158659
    • OTTHUMP00000158660
    • OTTHUMP00000203723
    • OTTHUMP00000203724
    • Paired box 8
    • Paired box gene 8
    • paired box homeotic gene 8
    • Paired box protein Pax 8
    • Paired box protein Pax-8
    • Paired domain gene 8
    • PAX 8
    • PAX8
    • PAX8_HUMAN
    see all
  • 功能Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.
  • 组织特异性Expressed in the excretory system, thyroid gland and Wilms tumors.
  • 疾病相关Defects in PAX8 are the cause of congenital hypothyroidism non-goitrous type 2 (CHNG2) [MIM:218700]. CHNG2 is a disease characterized by thyroid dysgenesis, the most frequent cause of congenital hypothyroidism, accounting for 85% of case. The thyroid gland can be completely absent (athyreosis), ectopically located and/or severely hypoplastic. Ectopic thyroid gland is the most frequent malformation, with thyroid tissue being found most often at the base of the tongue.
  • 序列相似性Contains 1 paired domain.
  • 发展阶段In developing excretory system, during thyroid differentiation and in adult thyroid.
  • 细胞定位Nucleus.
  • Information by UniProt

Recombinant Human PAX8 protein 图像

  • ab112376 analysed by 12.5% SDS-PAGE and stained with Coomassie Blue.

Recombinant Human PAX8 protein (ab112376)参考文献

ab112376 has not yet been referenced specifically in any publications.

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