Recombinant人PAR4 protein (ab114724)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ96IZ0
    • 种属Human
    • 序列SVSEEDVSSRYSRTDRSGFPRYNRDANVSGTLVSSSTLEKKIEDLEKEVV RERQENLRLVRLMQDKEEMIGKLKEEIDLLNRDLDDIEDENEQLKQENKT LLKVVGQLTR
    • 分子量38 kDa including tags
    • 氨基酸231 to 340
    • 标签GST tag N-Terminus

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技术指标

Our Abpromise guarantee covers the use of ab114724 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • 2310001G03Rik
    • PAR 4
    • PAR-4
    • Pawr
    • PAWR_HUMAN
    • PRKC Apoptosis WT1 Regulator
    • PRKC apoptosis WT1 regulator protein
    • Prostate apoptosis response 4 protein
    • Prostate apoptosis response protein 4
    • prostate apoptosis response protein PAR-4
    • Transcriptional repressor Par-4-like protein PAWR
    • Transcriptional repressor PAR4
    • WT1 Interacting Protein
    see all
  • 功能Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.
  • 组织特异性Widely expressed. Expression is elevated in various neurodegenerative diseases such as amyotrophic lateral sclerosis, Alzheimer, Parkinson and Huntington diseases and stroke. Down-regulated in several cancers.
  • 结构域The leucine-zipper domain is not essential for apoptosis, but is required for sensitization of cells to exogenous apoptotic insults and for interaction with its partners.
    The SAC domain is a death-inducing domain selective for apoptosis induction in cancer cells. This domain is essential for nuclear entry, Fas activation, inhibition of NF-kappa-B activity and induction of apoptosis in cancer cells.
  • 翻译后修饰Preferentially phosphorylated at the Thr-163 by PKC in cancer cells.
  • 细胞定位Cytoplasm. Nucleus. Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis (By similarity). Nuclear localization includes nucleoplasm and PML nuclear bodies.
  • Information by UniProt

Recombinant Human PAR4 protein 图像

  • 12.5% SDS-PAGE Stained with Coomassie Blue

Recombinant Human PAR4 protein (ab114724)参考文献

ab114724 has not yet been referenced specifically in any publications.

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