Recombinant人PAM protein (ab116776)

概述

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      FRVGGETGSKYFVLQVHYGDISAFRDNNKDCSGVSLHLTRLPQPLIAGMY LMMSVDTVIPAGEKVVNSDISCHYKNYPMHVFAYRVHTHHLGKVVSGYRV RNGQWTLI
    • 分子量
      38 kDa including tags
    • 氨基酸
      151 to 258

技术指标

Our Abpromise guarantee covers the use of ab116776 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    SDS-PAGE

    ELISA

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • AMD_HUMAN
    • PAL
    • PAM
    • Pancreatic peptidylglycine alpha amidating monooxygenase
    • Peptidyl alpha amidating enzyme
    • Peptidyl alpha hydroxyglycine alpha amidating lyase
    • Peptidyl-alpha-hydroxyglycine alpha-amidating lyase
    • Peptidylamidoglycolate lyase
    • Peptidylglycine 2 hydroxylase
    • Peptidylglycine alpha amidating monooxygenase
    • Peptidylglycine alpha hydroxylating monooxygenase
    • PHM
    see all
  • 功能
    Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.
  • 序列相似性
    In the C-terminal section; belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.
    In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family.
    Contains 5 NHL repeats.
  • 细胞定位
    Membrane and Secreted. Secreted from secretory granules.
  • Information by UniProt

图片

  • 12.5% SDS-PAGE showing ab116776 at approximately 37.51kDa.
    Stained with Coomassie Blue.

文献

ab116776 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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