概述
-
产品名称重组人PAI1蛋白
参阅全部 PAI1 蛋白酶 -
蛋白长度Protein fragment
描述
-
性质Recombinant
-
来源Escherichia coli
-
氨基酸序列
-
种属Human
-
技术指标
Our Abpromise guarantee covers the use of ab92871 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
-
生物活性<1% active
-
应用
SDS-PAGE
-
纯度> 95 % SDS-PAGE.
> 98% pure by SDS PAGE -
形式Liquid
-
补充说明
Solubility: > 2 mg/mL and < 5 mg/mL
ab92871 is a non-reactive, reactive loop inserted species of PAI1.
-
Concentration information loading...
制备和贮存
-
稳定性和存储
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Preservative: None
Constituents: 0.1M Sodium chloride, 0.05M Sodium phosphate, 1mM EDTA, pH 6.6This product is an active protein and may elicit a biological response in vivo, handle with caution.
常规信息
-
别名
- Clade E
- Endothelial plasminogen activator inhibitor
- Nexin
see all -
功能This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis.
-
组织特异性Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells.
-
疾病相关Defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1D) [MIM:613329]. It is a hematologic disorder characterized by increased bleeding after trauma, injury, or surgery. Affected females have menorrhagia. The bleeding defect is due to increased fibrinolysis of fibrin blood clots due to deficiency of plasminogen activator inhibitor-1, which inhibits tissue and urinary activators of plasminogen.
Note=High concentrations of SERPINE1 seem to contribute to the development of venous but not arterial occlusions. -
序列相似性Belongs to the serpin family.
-
翻译后修饰Inactivated by proteolytic attack of the urokinase-type (u-PA) and the tissue-type (TPA), cleaving the 369-Arg-
-Met-370 bond. -
细胞定位Secreted.
- Information by UniProt
图片
-
SDS-PAGE - PAI1 protein (Human) (ab92871)10% SDS-PAGE analysis
Lane 1: Human PAI1 (3µg) Reduced Lane 2: ab92871 (3µg) Reduced
Lane 3: Molecular weight markers
文献
ab92871 has not yet been referenced specifically in any publications.
客户评价及客户问答
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"