Pituitary adenylate cyclase activating polypeptide type I receptor precursor
Pituitary adenylate cyclase-activating polypeptide 1, receptor for
Pituitary adenylate cyclase-activating polypeptide type I receptor
功能This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.
组织特异性Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and placenta.
序列相似性Belongs to the G-protein coupled receptor 2 family.