Recombinant人p73 beta protein (ab102553)

概述

  • 产品名称Recombinant人p73 beta protein
  • 蛋白长度Full length protein

描述

  • 性质Recombinant
  • 来源Baculovirus infected Sf9 cells
  • 氨基酸序列
    • AccessionO15350-2
    • 种属Human
    • 分子量88 kDa including tags
    • 氨基酸1 to 499

技术指标

Our Abpromise guarantee covers the use of ab102553 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Western blot

  • 纯度> 90 % SDS-PAGE.
    Purity was determined to be >90% by densitometry.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

常规信息

  • 别名
    • p53 related protein
    • P73
    • TP73
    • Tumor protein p73
  • 相关性The p73 exhibits sequence homology to the p53's transcriptional activation, DNA binding, and oligomerization domains. However, adenovirus E1B 55K, simian virus 40 T, and human papillomavirus E6 do not physically interact with p73 indicating that the functions of these two proteins may differ under physiological conditions. Significant homology between p53, p63, and p73 (approximately 63% amino acid identity in the DNA binding domain suggest that they may have overlapping functions in the regulation of gene expression. p73 is expressed in either a full length form (a) (MW ~80kD) or a shorter (b) (MW ~70kD) mRNA variant, with exon 13 spliced out. Transient overexpression of p73 in cells can induce apoptosis and p21, a cellular p53 target gene primarily responsible for p53 dependent cell cycle arrest. The targeted disruption of p73 gene leads to defects hippocampal dysgenesis, hydrocephalus, chronic inflammation and infections. p73 is upregulated in a significant fraction of anaplastic thyroid cancers, whereas it is not detectable in normal thyroid epithelial cells nor in papillary or follicular thyroid cancer.
  • 细胞定位Nuclear

Recombinant Human p73 beta protein 图像

  • SDS-PAGE showing ab102553 at approximately 88kDa.

Recombinant Human p73 beta protein (ab102553)参考文献

ab102553 has not yet been referenced specifically in any publications.

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