Recombinant人p57 Kip2 protein (ab112270)

概述

  • 产品名称Recombinant人p57 Kip2 protein
  • 蛋白长度Protein fragment

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP49918
    • 种属Human
    • 序列MSDASLRSTSTMERLVARGTFPVLVRTSACRSLFGPVDHEELSRELQARL AELNAEDQNRWDYDFQQDMPLRGPGRLQWTEVDSDSVPAFYRETVQVGRC
    • 分子量37 kDa including tags
    • 氨基酸1 to 100
    • 标签GST tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab112270 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性useful for Antibody Production and Protein Array
  • 应用

    Peptide Array

    Western blot

    ELISA

    SDS-PAGE

  • 形式Liquid
  • 补充说明Best use within three months from the date of receipt of this protein.useful for Antibody Production and Protein Array
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione
    Note: Glutathione is reduced

常规信息

  • 别名
    • Beckwith Wiedemann syndrome
    • BWCR
    • BWS
    • CDKI
    • CDKN 1C
    • CDKN1C
    • CDN1C_HUMAN
    • Cyclin dependent kinase inhibitor 1C
    • Cyclin dependent kinase inhibitor p57
    • Cyclin-dependent kinase inhibitor 1C
    • Cyclin-dependent kinase inhibitor p57
    • KIP 2
    • KIP2
    • p57
    • p57 Kip 2
    • p57KIP2
    • WBS
    see all
  • 功能Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.
  • 组织特异性Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels are seen in the placenta while low levels are seen in the liver.
  • 疾病相关Defects in CDKN1C are a cause of Beckwith-Wiedemann syndrome (BWS) [MIM:130650]. BWS is a genetically heterogeneous disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth, and macroglossia. Additional less frequent complications include specific developmental defects and a predisposition to embryonal tumors.
    Note=Defects in CDKN1C are involved in tumor formation.
  • 序列相似性Belongs to the CDI family.
  • 细胞定位Nucleus.
  • Information by UniProt

Recombinant Human p57 Kip2 protein 图像

  • 12.5% SDS-PAGE Stained with Coomassie Blue.

Recombinant Human p57 Kip2 protein (ab112270)参考文献

ab112270 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab112270.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"