Recombinant人p35 + p25 protein (ab125653)

概述

描述

  • 性质Recombinant
  • 来源Baculovirus infected Sf9 cells
  • 氨基酸序列
    • AccessionQ15078
    • 种属Human
    • 分子量49 kDa including tags
    • 氨基酸98 to 307

技术指标

Our Abpromise guarantee covers the use of ab125653 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    SDS-PAGE

  • 纯度> 85 % Densitometry.
    Purity was determined to be >85% by densitometry.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.88% Sodium chloride

常规信息

  • 别名
    • CDK5
    • CDK5 activator 1
    • CDK5P35
    • CDK5R
    • CDK5R1
    • Cyclin dependent kinase 5 activator 1
    • Cyclin dependent kinase 5 regulatory subunit 1
    • Cyclin dependent kinase 5, regulatory subunit 1 (p35)
    • Cyclin-dependent kinase 5
    • NCK5A
    • Neuronal CDK5 activator
    • p23
    • p25
    • p35
    • P35nck5a
    • PSSALRE
    • Regulatory partner for CDK5 kinase
    • Tau protein kinase II 23kDa subunit
    • TPKII regulatory subunit
    see all
  • 相关性p35 is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.
  • 细胞定位Cell Membrane, Cytoplasmic and Nuclear

Recombinant Human p35 + p25 protein 图像

  • SDS-PAGE analysis of ab125653.

Recombinant Human p35 + p25 protein (ab125653)参考文献

ab125653 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab125653.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"