Recombinant人p18 INK4c protein (ab119460)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MGSSHHHHHHSSGLVPRGSHMAEPWGNELASAAARGDLEQLTSLLQNNVN VNAQNGFGRTALQVMKLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARA GFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV GHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ
    • 分子量
      21 kDa including tags
    • 氨基酸
      1 to 168
    • 标签
      His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab119460 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Mass Spectrometry

    SDS-PAGE

  • 质谱法
    MALDI-TOF
  • 纯度
    > 95 % SDS-PAGE.
    ab119460 was purified using conventional chromatography techniques.
  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.03% DTT, 10% Glycerol, 1.17% Sodium chloride

常规信息

  • 别名
    • CDK6 inhibitor p18
    • CDKN 2C
    • CDKN 6
    • Cdkn2c
    • CDKN6
    • CDN2C_HUMAN
    • Cyclin dependent inhibitor
    • Cyclin dependent kinase 4 inhibitor C
    • Cyclin dependent kinase 6 inhibitor
    • Cyclin dependent kinase 6 inhibitor p18
    • Cyclin dependent kinase inhibitor 2C
    • Cyclin dependent kinase inhibitor 2C (p18 inhibits CDK4)
    • Cyclin-dependent kinase 4 inhibitor C
    • Cyclin-dependent kinase 6 inhibitor
    • INK4C
    • OTTHUMP00000046546
    • p18
    • p18 inhibits CDK4
    • p18 INK4c
    • p18 INK6
    • p18-INK4c
    • p18-INK6
    see all
  • 功能
    Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.
  • 组织特异性
    Highest levels found in skeletal muscle. Also found in pancreas and heart.
  • 序列相似性
    Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
    Contains 4 ANK repeats.
  • Information by UniProt

图片

  • 15% SDS-PAGE showing ab119460 at approximately 20.7kDa (3µg).

文献

ab119460 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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