Recombinant人P protein (ab116803)

概述

  • 产品名称Recombinant人P protein
  • 蛋白长度Protein fragment

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ04671
    • 种属Human
    • 序列GKLWQLLALSPLENYSVNLSSHVDSTLLQVDLAGALVASGPSRPGREE HIVVELTQADALGSRWRRPQQVTHNWTVYLNPRRSEHSVMSRTFEVLTRE TV
    • 分子量37 kDa including tags
    • 氨基酸201 to 300

技术指标

Our Abpromise guarantee covers the use of ab116803 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    Western blot

    SDS-PAGE

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    This protein is best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

常规信息

  • 别名
    • BEY
    • BEY1
    • BEY2
    • BOCA
    • D15S12
    • EYCL
    • EYCL2
    • EYCL3
    • eye color 2 (central brown)
    • eye color 3 (brown)
    • hair color 3 (brown)
    • HCL3
    • Melanocyte-specific transporter protein
    • OCA2
    • oculocutaneous albinism II
    • oculocutaneous albinism II (pink-eye dilution homolog, mouse)
    • P
    • P protein
    • P_HUMAN
    • PED
    • Pink eyed dilution protein homolog
    • Pink-eyed dilution protein homolog
    • SHEP1
    • total brown iris pigmentation
    see all
  • 功能Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color.
  • 疾病相关Defects in OCA2 are the cause of albinism oculocutaneous type 2 (OCA2) [MIM:203200]. An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. Although affected infants may appear at birth to have complete absence of melanin pigment, most patients acquire small amounts of pigment with age. Visual anomalies include decreased acuity and nystagmus. The phenotype is highly variable. The hair of affected individuals may turn darker with age, and pigmented nevi or freckles may be seen. African and African American individuals may have yellow hair and blue-gray or hazel irides. One phenotypic variant, 'brown OCA,' has been described in African and African American populations and is characterized by light brown hair and skin color and gray to tan irides.
  • 序列相似性Belongs to the CitM (TC 2.A.11) transporter family.
  • 细胞定位Melanosome membrane.
  • Information by UniProt

Recombinant Human P protein 图像

  • 12.5% SDS-PAGE showing ab116803 at approximately 36.63kDa.
    Stained with Coomassie Blue.

Recombinant Human P protein (ab116803)参考文献

ab116803 has not yet been referenced specifically in any publications.

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