Recombinant人ORC4L protein (ab114619)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionO43929
    • 种属Human
    • 序列MSSRKSKSNSLIHTECLSQVQRILRERFCRQSPHSNLFGVQVQYKHLSEL LKRTALHGESNSVLIIGPRGSGKTMLISHALKELMEIEEVSENVLQVHLN GLLQINDKIALKEITRQLNLENVVGDKVFGSFAENLSFLLEALKKGDRTS SCPVIFILDEFDLFAHHKNQTLLYNLFDISQSAQTPIAVIGLTCRLDILE LLEKRVKSRFSHRQIHLMNSFGFPQYVKIFKEQLSLPAEFPDKVFAEK
    • 分子量53 kDa including tags
    • 氨基酸1 to 248

技术指标

Our Abpromise guarantee covers the use of ab114619 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    ELISA

    SDS-PAGE

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    This protein is best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

常规信息

  • 别名
    • Origin recognition complex, subunit 4, S. cerevisiae, homolog of
    • FLJ46668
    • HSORC4
    • ORC 4
    • ORC 4L
    • ORC 4P
    • ORC4
    • ORC4_HUMAN
    • ORC4L
    • ORC4L protein
    • ORC4P
    • Origin recognition complex subunit 4
    • Origin recognition complex subunit 4 (yeast homolog) like
    • Origin recognition complex subunit 4 like
    • Origin recognition complex subunit 4 like (yeast)
    • origin recognition complex, subunit 4 homolog
    • Origin recognition complex, subunit 4, S. cerevisiae, homolog-like
    see all
  • 功能Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
  • 疾病相关Defects in ORC4 are the cause of Meier-Gorlin syndrome type 2 (MGORS2) [MIM:613800]. MGORS2 is a syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal.
  • 序列相似性Belongs to the ORC4 family.
  • 细胞定位Nucleus.
  • Information by UniProt

Recombinant Human ORC4L protein 图像

  • ab114619 analysed on a 12.5% SDS-PAGE stained with Coomassie Blue.

Recombinant Human ORC4L protein (ab114619)参考文献

ab114619 has not yet been referenced specifically in any publications.

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