概述

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
      Q13516
    • 种属
      Human
    • 序列
      MDSDASLVSSRPSSPEPDDLFLPARSKGSSGSAFTGGTVSSSTPSDCPPE LSAELRGAMGSAGAHPVDKLGGSGFKSSSSSTSSSTSSAAASSTKKDKKQ MTEPELQQLRLKINSRERKRMHDLNIAMDGLREVMPYAHGPSVRKLSKIA TLLLARNYILMLTNSLEEMKRLVSEIYGGHHAGFHPSACGGLAHSAPLPA ATAHPAAAAHAAHHPAVHHPILPPAAAAAAAAAAAAAVSSASLPGSGLPS VGSIRPPHGLLKSPSAAAAAPLGGGGGGSGASGGFQHWGGMPCPCSMCQV PPPHHHVSAMGAGSLPRLTSDAK
    • 分子量
      62 kDa including tags
    • 氨基酸
      1 to 323

技术指标

Our Abpromise guarantee covers the use of ab112389 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Other

    Western blot

  • 形式
    Liquid
  • 补充说明
    Best to use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione
    Note: Glutathione is reduced

常规信息

  • 别名
    • Basic domain helix loop helix protein class B 1
    • Basic helix loop helix protein class B 1
    • BHLHB
    • bHLHB1
    • bHLHe19
    • Class B basic helix loop helix protein 1
    • Class B basic helix-loop-helix protein 1
    • class E basic helix loop helix protein 19
    • Class E basic helix-loop-helix protein 19
    • Human protein kinase C binding protein RACK17
    • Olig2
    • OLIG2_HUMAN
    • Oligo2
    • Oligodendrocyte lineage transcription factor 2
    • Oligodendrocyte specific bHLH transcription factor 2
    • Oligodendrocyte transcription factor 2
    • OTTHUMP00000067569
    • OTTHUMP00000067570
    • PRKCBP2
    • Protein kinase C binding protein 2
    • Protein kinase C binding protein RACK17
    • Protein kinase C-binding protein 2
    • Protein kinase C-binding protein RACK17
    • RACK17
    see all
  • 功能
    Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development.
  • 组织特异性
    Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.
  • 疾病相关
    Note=A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA.
  • 序列相似性
    Contains 1 basic helix-loop-helix (bHLH) domain.
  • 结构域
    The bHLH is essential for interaction with NKX2-2.
  • 细胞定位
    Nucleus. Cytoplasm. The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2.
  • Information by UniProt

图片

  • SDS-PAGE - Olig2 protein (ab112389)
    SDS-PAGE - Olig2 protein (ab112389)
    12.5% SDS-PAGE analysis of ab112389. Stained with Coomassie Blue.

文献

ab112389 has not yet been referenced specifically in any publications.

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