概述
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产品名称Recombinant人Olig2 protein
参阅全部 Olig2 蛋白酶 -
蛋白长度Full length protein
描述
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性质Recombinant
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来源Wheat germ
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氨基酸序列
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Accession
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种属Human
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序列MDSDASLVSSRPSSPEPDDLFLPARSKGSSGSAFTGGTVSSSTPSDCPPE LSAELRGAMGSAGAHPVDKLGGSGFKSSSSSTSSSTSSAAASSTKKDKKQ MTEPELQQLRLKINSRERKRMHDLNIAMDGLREVMPYAHGPSVRKLSKIA TLLLARNYILMLTNSLEEMKRLVSEIYGGHHAGFHPSACGGLAHSAPLPA ATAHPAAAAHAAHHPAVHHPILPPAAAAAAAAAAAAAVSSASLPGSGLPS VGSIRPPHGLLKSPSAAAAAPLGGGGGGSGASGGFQHWGGMPCPCSMCQV PPPHHHVSAMGAGSLPRLTSDAK
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分子量62 kDa including tags
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氨基酸1 to 323
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相关产品
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Related Products
技术指标
Our Abpromise guarantee covers the use of ab112389 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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应用
ELISA
SDS-PAGE
Other
Western blot
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形式Liquid
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补充说明Best to use within three months from the date of receipt of this protein.
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Concentration information loading...
制备和贮存
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稳定性和存储
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Note: Glutathione is reduced
常规信息
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别名
- Basic domain helix loop helix protein class B 1
- Basic helix loop helix protein class B 1
- BHLHB
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功能Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development.
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组织特异性Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.
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疾病相关Note=A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA.
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序列相似性Contains 1 basic helix-loop-helix (bHLH) domain.
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结构域The bHLH is essential for interaction with NKX2-2.
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细胞定位Nucleus. Cytoplasm. The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2.
- Information by UniProt
Recombinant Human Olig2 protein 图像
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SDS-PAGE - Olig2 protein (ab112389)12.5% SDS-PAGE analysis of ab112389. Stained with Coomassie Blue.
Recombinant Human Olig2 protein (ab112389)参考文献
ab112389 has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"