Recombinant人OGT / O-Linked N-Acetylglucosamine Transferase protein (ab91749)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human
    • 序列SQIPCNGKAADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWL GYPGTSGALFMDYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANM FPHLKKKAVIDFKSNGHIYDNRIVLNGIDLKAFLDSLPDVKIVKMKCP DGGDNADSSNTALNMPVIPMNTIAEAVIEMINRGQIQITINGFSISNG LATTQINNKAATGEEVPRTIIVTTRSQYGLPEDAIVYCNFNQLYKIDP STLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQNMGLPQNRIIFS PVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMPGETL ASRVAASQLTCLGCLELIAKNRQEYEDIAVKLGTDLEYLKKVRGKVWK QRISSPLFNTKQYTMELERLYLQMWEHYAAGNK
    • 氨基酸606 to 1022

技术指标

Our Abpromise guarantee covers the use of ab91749 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 形式Lyophilised
  • 补充说明Protein Identity confirmed by Mass Spectrometry (MS/MS) (acquired on initial reference batch).
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5

  • 复溶Reconstitute with 81 µl aqua dest.

常规信息

  • 别名
    • FLJ23071
    • GlcNAc transferase
    • HRNT1
    • MGC22921
    • O GlcNAc
    • O GlcNAc transferase p110 subunit
    • O GlcNAc transferase subunit p110
    • O linked N acetylglucosamine (GlcNAc) transferase
    • O linked N acetylglucosamine (GlcNAc) transferase (UDP N acetylglucosamine:polypeptide N acetylglucosaminyl transferase)
    • O linked N acetylglucosamine transferase 110 kDa subunit
    • O-GlcNAc transferase subunit p110
    • O-linked N-acetylglucosamine transferase 110 kDa subunit
    • ogt
    • OGT1_HUMAN
    • UDP N acetylglucosamine peptide N acetylglucosaminyltransferase 110 kDa subunit
    • UDP N acetylglucosamine peptide N acetylglucosaminyltransferase GlcNAc transferase
    • UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
    • UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase
    • Uridinediphospho N acetylglucosamine:polypeptide beta N acetylglucosaminyl transferase
    see all
  • 功能Addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine. Mediates the O-glycosylation of MLL5 and HCFC1. Promotes proteolytic maturation of HCFC1.
  • 组织特异性Highly expressed in pancreas and to a lesser extent in skeletal muscle, heart, brain and placenta. Present in trace amounts in lung and liver.
  • 通路Protein modification; protein glycosylation.
  • 序列相似性Belongs to the O-GlcNAc transferase family.
    Contains 13 TPR repeats.
  • 结构域The TPR repeat domain mediates recognition of protein substrates.
  • 翻译后修饰Ubiquitinated, leading to its proteasomal degradation.
  • 细胞定位Cytoplasm. Nucleus. Mostly in the nucleus.
  • Information by UniProt

Recombinant Human OGT / O-Linked N-Acetylglucosamine Transferase protein 图像

  • The image shows an electrophoretic assay performed using an Agilent 5100 ALP. In some images coloured control bands can be seen at 15 kDa (green) and/or 240 kDa (purple). The protein-specific band is blue.

Recombinant Human OGT / O-Linked N-Acetylglucosamine Transferase protein (ab91749)参考文献

ab91749 has not yet been referenced specifically in any publications.

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