Recombinant人Occludin protein (ab114190)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ16625
    • 种属Human
    • 序列ITSDQQRQLYKRNFDTGLQEYKSLQSELDEINKELSRLDKELDDYREESE EYMAAADEYNRLKQVKGSADYKSKKNHCKQLKSKLSHIKKMVGDYDRQKT
    • 分子量37 kDa including tags
    • 氨基酸423 to 522

技术指标

Our Abpromise guarantee covers the use of ab114190 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    Western blot

    SDS-PAGE

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • BLCPMG
    • FLJ08163
    • FLJ18079
    • FLJ77961
    • FLJ94056
    • MGC34277
    • Occludin
    • Ocln
    • OCLN_HUMAN
    • Tight junction protein occludin
    see all
  • 功能May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions.
  • 组织特异性Localized at tight junctions of both epithelial and endothelial cells. Highly expressed in kidney. Not detected in testis.
  • 疾病相关Defects in OCLN are the cause of band-like calcification with simplified gyration and polymicrogyria (BLCPMG) [MIM:251290]; also known as pseudo-TORCH syndrome. BLCPMG is a neurologic disorder with characteristic clinical and neuroradiologic features that mimic intrauterine TORCH infection in the absence of evidence of infection. Affected individuals have congenital microcephaly, intracranial calcifications, and severe developmental delay.
  • 序列相似性Belongs to the ELL/occludin family.
    Contains 1 MARVEL domain.
  • 结构域The C-terminal is cytoplasmic and is important for interaction with ZO-1. Sufficient for the tight junction localization. Involved in the regulation of the permeability barrier function of the tight junction (By similarity). The first extracellular loop participates in an adhesive interaction.
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR. Dephosphorylated by PTPRJ. The tyrosine phosphorylation on Tyr-398 and Tyr-402 reduces its ability to interact with TJP1.
  • 细胞定位Membrane. Cell junction > tight junction.
  • Information by UniProt

Recombinant Human Occludin protein 图像

  • ab114190 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

Recombinant Human Occludin protein (ab114190)参考文献

ab114190 has not yet been referenced specifically in any publications.

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