Solute carrier organic anion transporter family member 1B1
功能Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. May play an important role in the clearance of bile acids and organic anions from the liver.
组织特异性Highly expressed in liver. Not detected in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte.
序列相似性Belongs to the organo anion transporter (TC 2.A.60) family. Contains 1 Kazal-like domain.
细胞定位Basolateral cell membrane. Detected in basolateral membranes of hepatocytes.