Recombinant人NUAK2 protein (ab105209)

概述

描述

  • 性质Recombinant
  • 来源Baculovirus infected Sf9 cells
  • 氨基酸序列
    • AccessionQ9H093
    • 种属Human
    • 分子量110 kDa including tags
    • 氨基酸1 to 628

技术指标

Our Abpromise guarantee covers the use of ab105209 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性The Specific activity of ab105209 was determined to be 80 nmol/min/mg.
  • 应用

    SDS-PAGE

    Western blot

    Functional Studies

  • 纯度> 75 % SDS-PAGE.
    Purity was determined to be >75% by densitometry.
  • 形式Liquid
  • 补充说明

    ab204854 (Cdc25C peptide) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • DKFZp434J037
    • DKFZp686F01113
    • FLJ90349
    • NUAK family SNF1 like kinase 2
    • NUAK family SNF1-like kinase 2
    • Nuak2
    • NUAK2_HUMAN
    • Omphalocele kinase 2
    • SNARK
    • SNF1/AMP activated protein kinase
    • SNF1/AMP kinase related kinase
    • SNF1/AMP kinase-related kinase
    see all
  • 功能Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1.
  • 序列相似性Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
    Contains 1 protein kinase domain.
  • 翻译后修饰Phosphorylated at Thr-208 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Autophosphorylated in vitro.
  • Information by UniProt

Recombinant human NUAK2 protein 图像

  • The Specific activity of ab105209 was determined to be 80 nmol/min/mg.
  • SDS-PAGE showing ab105209 at approximately 110kDa.

Recombinant human NUAK2 protein (ab105209)参考文献

ab105209 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab105209.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"