Recombinant人NTAL protein (ab95498)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ9GZY6
    • 种属Human
    • 序列MGSSHHHHHH SSGLVPRGSH MRCSRPGAKR SEKIYQQRSL REDQQSFTGS RTYSLVGQAW PGPLADMAPT RKDKLLQFYP SLEDPASSRY QNFSKGSRHG SEEAYIDPIA MEYYNWGRFS KPPEDDDANS YENVLICKQK TTETGAQQEG IGGLCRGDLS LSLALKTGPT SGLCPSASPE EDEESEDYQN SASIHQWRES RKVMGQLQRE ASPGPVGSPD EEDGEPDYVN GEVAATEA
    • 分子量26 kDa including tags
    • 氨基酸27 to 243
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab95498 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Mass Spectrometry

    SDS-PAGE

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, 20mM Tris HCl, pH 8.0

常规信息

  • 别名
    • HSPC046
    • LAB
    • LAT2
    • Linker for activation of B cells
    • Linker for activation of B-cells
    • Linker for activation of T cells family member 2
    • Linker for activation of T cells transmembrane adaptor 2
    • Linker for activation of T-cells family member 2
    • Membrane associated adapter molecule
    • Membrane-associated adapter molecule
    • Non T cell activation linker
    • Non-T-cell activation linker
    • NTAL_HUMAN
    • WBSCR 5
    • Wbscr15
    • Williams Beuren syndrome chromosome region 15
    • Williams Beuren syndrome chromosome region 5
    • Williams-Beuren syndrome chromosomal region 15 protein
    • Williams-Beuren syndrome chromosomal region 5 protein
    • WSCR5
    see all
  • 功能Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.
  • 组织特异性Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level).
  • 疾病相关Note=LAT2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of LAT2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
  • 翻译后修饰Phosphorylated on tyrosines following cross-linking of BCR in B-cells, FCGR1 in myeloid cells, or FCER1 in mast cells; which induces the recruitment of GRB2.
    May be polyubiquitinated.
  • 细胞定位Cell membrane. Present in lipid rafts.
  • Information by UniProt

Recombinant Human NTAL protein 图像

  • 15% SDS-PAGE analysis of 3µg ab95498.

Recombinant Human NTAL protein (ab95498)参考文献

ab95498 has not yet been referenced specifically in any publications.

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