Recombinant人NSMase2 protein (ab112416)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ9NY59
    • 种属Human
    • 分子量98 kDa including tags
    • 氨基酸1 to 655

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技术指标

Our Abpromise guarantee covers the use of ab112416 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性useful for Antibody Production and Protein Array
  • 应用

    SDS-PAGE

    Western blot

    ELISA

  • 形式Liquid
  • 补充说明Best use within three months from the date of receipt of this protein.useful for Antibody Production and Protein Array
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione
    Note: (Glutathione is reduced)

常规信息

  • 别名
    • Cca1
    • Confluent 3Y1 cell-associated protein 1
    • Neutral sphingomyelinase 2
    • Neutral sphingomyelinase II
    • NSMA2_HUMAN
    • nSMase-2
    • nSMase2
    • SMPD3
    • Sphingomyelin phosphodiesterase 3
    • sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
    see all
  • 功能Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization.
  • 组织特异性Predominantly expressed in brain.
  • 序列相似性Belongs to the neutral sphingomyelinase family.
  • 发展阶段Up-regulated during G0/G1 phases.
  • 细胞定位Golgi apparatus membrane. Cell membrane. May localize to detergent-resistant subdomains of Golgi membranes of hypothalamic neurosecretory neurons. According to PubMed:15051724, it localizes to plasma membrane in confluent contact-inhibited cells.
  • Information by UniProt

Recombinant Human NSMase2 protein 图像

  • 12.5% SDS-PAGE stained with Coomassie Blue.

Recombinant Human NSMase2 protein (ab112416)参考文献

ab112416 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"