The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 µg/µl.
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Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Adult T cell leukemia derived PMA responsive
Immediate early response protein APR
Immediate-early-response protein APR
Phorbol 12 myristate 13 acetate induced protein 1
Phorbol-12-myristate-13-acetate-induced protein 1
PMA induced protein 1
PMA-induced protein 1
Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
Highly expressed in adult T-cell leukemia cell line.
Belongs to the PMAIP1 family.
The BH3 motif is essential for pro-apoptotic activity.