Recombinant人NKIRAS2 protein (ab124599)

概述

  • 产品名称Recombinant人NKIRAS2 protein
  • 蛋白长度Full length protein

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ9NYR9
    • 种属Human
    • 序列MGSSHHHHHH SSGLVPRGSH MGSHMGKSCK VVVCGQASVG KTSILEQLLY GNHVVGSEMI ETQEDIYVGS IETDRGVREQ VRFYDTRGLR DGAELPRHCF SCTDGYVLVY STDSRESFQR VELLKKEIDK SKDKKEVTIV VLGNKCDLQE QRRVDPDVAQ HWAKSEKVKL WEVSVADRRS LLEPFVYLAS KMTQPQSKSA FPLSRKNKGS GSLDG
    • 分子量24 kDa including tags
    • 氨基酸1 to 191
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab124599 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度> 90 % SDS-PAGE.
    ab124599 is purified by using conventional chromatography techniques.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 10% Glycerol, 0.58% Sodium chloride

常规信息

  • 别名
    • DKFZP434N1526
    • I kappa B interacting Ras like protein 2
    • I-kappa-B-interacting Ras-like protein 2
    • Kappa B Ras protein 2
    • Kappa B-Ras protein 2
    • KappaB Ras2
    • KappaB-Ras2
    • KBRAS 2
    • KBRAS2
    • KBRS2_HUMAN
    • MGC74742
    • NF kappa B inhibitor interacting Ras like protein 2
    • NF-kappa-B inhibitor-interacting Ras-like protein 2
    • NFKB inhibitor interacting Ras like 2
    • NFKB inhibitor interacting Ras like protein 2
    • NKIRAS 2
    • NKIRAS2
    see all
  • 功能Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.
  • 组织特异性Widely expressed.
  • 序列相似性Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.
  • 结构域In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Ala and Leu residues, respectively, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.
  • 细胞定位Cytoplasm.
  • Information by UniProt

Recombinant Human NKIRAS2 protein 图像

  • 15% SDS-PAGE showing ab124599 (3µg).

Recombinant Human NKIRAS2 protein (ab124599)参考文献

ab124599 has not yet been referenced specifically in any publications.

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