Recombinant人NKIRAS1 protein (ab123143)

概述

  • 产品名称
    Recombinant人NKIRAS1 protein
  • 蛋白长度
    Full length protein

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MGSSHHHHHHSSGLVPRGSHMGKGCKVVVCGLLSVGKTAILEQLLYGNHT IGMEDCETMEDVYMASVETDRGVKEQLHLYDTRGLQEGVELPKHYFSFAD GFVLVYSVNNLESFQRVELLKKEIDKFKDKKEVAIVVLGNKIDLSEQRQV DAEVAQQWAKSEKVRLWEVTVTDRKTLIEPFTLLASKLSQPQSKSSFPLP GRKNKGNSNSEN
    • 分子量
      24 kDa including tags
    • 氨基酸
      1 to 192
    • 标签
      His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab123143 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度
    > 95 % SDS-PAGE.
    ab123143 was purified using conventional chromatography.
  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 20% Glycerol

常规信息

  • 别名
    • 2400004O09Rik
    • I kappa B interacting Ras like protein 1
    • I-kappa-B-interacting Ras-like protein 1
    • Kappa B Ras 1
    • Kappa B Ras protein 1
    • Kappa B-Ras protein 1
    • KappaB Ras1
    • KappaB-Ras1
    • KBRAS 1
    • KBRAS1
    • KBRS1_HUMAN
    • NF kappa B inhibitor interacting Ras like protein 1
    • NF-kappa-B inhibitor-interacting Ras-like protein 1
    • NFKB inhibitor interacting Ras like 1
    • NFKB inhibitor interacting Ras like protein 1
    • NKIRAS 1
    • nkiras1
    see all
  • 功能
    Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.
  • 组织特异性
    Widely expressed.
  • 序列相似性
    Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.
  • 结构域
    In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Leu residues, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.
  • 细胞定位
    Cytoplasm.
  • Information by UniProt

图片

  • 12% SDS PAGE, 3 µg of ab123143 loaded.

文献

ab123143 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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