Recombinant人Nicotinic Acetylcholine Receptor epsilon protein (ab114817)

概述

  • 产品名称Recombinant人Nicotinic Acetylcholine Receptor epsilon protein
  • 蛋白长度Protein fragment

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ04844
    • 种属Human
    • 序列KNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKEETL TTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQF GVAYDANVLV
    • 分子量38 kDa including tags
    • 氨基酸21 to 130

技术指标

Our Abpromise guarantee covers the use of ab114817 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • Acetylcholine receptor subunit epsilon
    • ACHE_HUMAN
    • AChR
    • AchR epsilon subunit
    • ACHRE
    • Cholinergic receptor, nicotinic, epsilon polypeptide
    • Chrne
    • CMS1D
    • CMS1E
    • CMS2A
    • FCCMS
    • SCCMS
    see all
  • 功能After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
  • 疾病相关The muscle AChR is the major target antigen in the autoimmune disease myasthenia gravis. Myasthenia gravis is characterized by sporadic muscular fatigability and weakness, occurring chiefly in muscles innervated by cranial nerves, and characteristically improved by cholinesterase-inhibiting drugs.
    Myasthenic syndrome, congenital, 4A, slow-channel
    Myasthenic syndrome, congenital, 4B, fast-channel
    Myasthenic syndrome, congenital, 4C, associated with acetylcholine receptor deficiency
  • 序列相似性Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Epsilon/CHRNE sub-subfamily.
  • 细胞定位Cell junction, synapse, postsynaptic cell membrane. Cell membrane.
  • Information by UniProt

Recombinant Human Nicotinic Acetylcholine Receptor epsilon protein 图像

  • 12.5% SDS-PAGE Stained with Coomassie Blue

Recombinant Human Nicotinic Acetylcholine Receptor epsilon protein (ab114817)参考文献

ab114817 has not yet been referenced specifically in any publications.

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